在尼日利亚参加抗逆转录病毒治疗诊所的患者中,人类免疫缺陷病毒感染和获得性免疫缺陷综合征的玻璃体视网膜表现:一项横断面研究

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Journal of Clinical Sciences Pub Date : 2022-07-01 DOI:10.4103/jcls.jcls_9_22
Y. Babalola, T. Oluleye, A. Ashaye
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引用次数: 1

摘要

背景:人类免疫缺陷病毒感染和获得性免疫缺陷综合征(HIV/AIDS)是一种多系统疾病,其已知表现包括眼眶和眼附件、视网膜和玻璃体前段的所有眼部结构。其中一些表现包括巨细胞病毒(CMV)视网膜炎和HIV视网膜病变是HIV/ aids的定义疾病。本研究的目的是确定在尼日利亚参加抗逆转录病毒治疗诊所的艾滋病毒/艾滋病患者的玻璃体视网膜表现。方法:这是一项前瞻性、横断面研究,研究对象是尼日利亚一家抗逆转录病毒治疗诊所中同意并确诊的艾滋病毒/艾滋病患者。招募了所有自愿的、连续的、给予知情同意的患者。社会人口统计数据和临床信息是用结构化的访谈者管理的问卷收集的。记录最佳矫正视力。用笔炬检查眼前节和眼附件。采用Volks +78屈光度的裂隙灯生物显微镜和双眼间接检眼镜对前后段进行了详细的检查。使用SPSS(社会科学统计软件包)16版对数据进行分析。获得了机构伦理委员会的伦理批准。结果:研究了318例患者,其中85例(26.7%)有视网膜和玻璃体病变。男女比例为2:1。超过三分之一(38.7%)的患者年龄在40-49岁之间,平均年龄为47.2岁。最常见的玻璃体视网膜病变被认为是眼部弓形虫病,在所有应答者中占9.7%。紧随其后的是3.5%的HIV视网膜病变、1.8%的眼结核和1.6%的CMV视网膜炎。277例(87.1%)接受了高效抗逆转录病毒治疗,41例(12.9%)未接受治疗。结论:在尼日利亚一家三级医院抗逆转录病毒治疗诊所就诊的艾滋病毒/艾滋病患者中,眼部疾病,特别是影响视网膜和玻璃体的疾病的患病率很高。建议对这些患者进行定期眼科检查,以防止潜在的视力衰弱障碍。
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Vitreoretinal manifestations of human immunodeficiency virus infection and acquired immunodeficiency syndrome in patients attending an antiretroviral therapy clinic in Nigeria: A cross sectional study
Background: The human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a multi-systemic disease with known manifestations involving all ocular structures from the orbit and ocular adnexa, anterior segment to the retina and vitreous. Some of these manifestations including cytomegalovirus (CMV) retinitis and HIV retinopathy are HIV/AIDS-defining illnesses. The aim of this study is to determine the vitreoretinal manifestations in patients with HIV/AIDS attending an antiretroviral therapy clinic in Nigeria. Methods: This was a prospective, cross-sectional study of consenting, confirmed HIV/AIDS patients attending an antiretroviral therapy clinic in Nigeria. All willing, consecutive patients who gave an informed consent were recruited. Sociodemographic data and clinical information were collected with the use of a structured interviewer–administered questionnaire. Best-corrected visual acuity was recorded. Anterior segment and ocular adnexa examination was performed with a pen torch. Detailed anterior and posterior segment examination was performed with slit lamp biomicroscopy with Volks +78 diopter lens and binocular indirect ophthalmoscopy. The data were analyzed with SPSS (statistical package for social sciences) version 16. Ethical approval was obtained from the institutional ethics committee. Results: Three hundred and eighteen patients were studied of which 85 (26.7%) had disorders affecting the retina and vitreous. The female-to-male ratio was 2:1. More than a third of patients (38.7%) were in the 40–49 years of age group and the mean age was 47.2 years. The most common vitreoretinal lesion was presumed ocular toxoplasmosis present in 9.7% of all respondents. This was closely followed by HIV retinopathy in 3.5%, ocular tuberculosis in 1.8%, and CMV retinitis in 1.6% respondents. Two hundred and seventy-seven (87.1%) respondents were on highly active antiretroviral therapy and 41 (12.9%) were not on treatment. Conclusion: A high prevalence of ocular conditions especially those affecting the retina and vitreous exists in patients with HIV/AIDS attending the antiretroviral therapy clinic in a tertiary hospital in Nigeria. Regular eye examinations are recommended for these patients to prevent potentially visual debilitating disorders.
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Journal of Clinical Sciences
Journal of Clinical Sciences MEDICINE, GENERAL & INTERNAL-
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15
审稿时长
45 weeks
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