{"title":"有蹄草减少去卵巢大鼠主动脉内膜-中膜厚度,增加主动脉直径和血管新生","authors":"Dwi Yulinda, Y. Yueniwati, T. Nurseta","doi":"10.5455/JEIM.140414.BR.022","DOIUrl":null,"url":null,"abstract":"Objective: This study aimed to determine whether Vigna unguiculata is able to affect aortic intima media thickness, aortic diameter and aortic VEGF expression among ovariectomized rats. Methods: Thirty female rats were divided into 5 groups (n = 6 each) including 1 control group (sham), one ovariectomized (OVX) group, and three test groups. The test rats were OVX group received 0.5 mg/kg body weight (BW), 2.5 mg/kg BW and 5 mg/kg BW of Vigna unguiculata extract. Aortic intima-media thickness was analyzed histologically. Aortic diameter was analyzed in abdominal aorta using ultrasonography. Aortic VEGF expression was analyzed immunohistochemically. Results: OVX decreased the aortic VEGF expression which was significantly elevated by the 5 mg/kg dose of V.unguiculata. OVX also significantly increased aortic intima-media thickness. This increase significantly reversed by the 5 mg/kg dose of the extract. In addition, the aortic diameter in OVX rats was significantly elevated by the 2.5 and 5 mg/kg doses of V.unguiculata extract. Conclusion: Vigna unguiculata extract elevated the decreased angiogenesis and aortic diameter in ovariectomized rats. Besides, the extract also decreased the aortic intima-media thickness. These results provide an alternative natural therapy for vascular pathology in the used experimental model. ©� 2014 GESDAV","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"10 1","pages":"85-88"},"PeriodicalIF":0.0000,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Vigna unguiculata reduces aortic intima-media thickness and increases aortic diameter and angiogenesis in ovariectomized rats\",\"authors\":\"Dwi Yulinda, Y. Yueniwati, T. Nurseta\",\"doi\":\"10.5455/JEIM.140414.BR.022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: This study aimed to determine whether Vigna unguiculata is able to affect aortic intima media thickness, aortic diameter and aortic VEGF expression among ovariectomized rats. Methods: Thirty female rats were divided into 5 groups (n = 6 each) including 1 control group (sham), one ovariectomized (OVX) group, and three test groups. The test rats were OVX group received 0.5 mg/kg body weight (BW), 2.5 mg/kg BW and 5 mg/kg BW of Vigna unguiculata extract. Aortic intima-media thickness was analyzed histologically. Aortic diameter was analyzed in abdominal aorta using ultrasonography. Aortic VEGF expression was analyzed immunohistochemically. Results: OVX decreased the aortic VEGF expression which was significantly elevated by the 5 mg/kg dose of V.unguiculata. OVX also significantly increased aortic intima-media thickness. This increase significantly reversed by the 5 mg/kg dose of the extract. In addition, the aortic diameter in OVX rats was significantly elevated by the 2.5 and 5 mg/kg doses of V.unguiculata extract. Conclusion: Vigna unguiculata extract elevated the decreased angiogenesis and aortic diameter in ovariectomized rats. Besides, the extract also decreased the aortic intima-media thickness. These results provide an alternative natural therapy for vascular pathology in the used experimental model. ©� 2014 GESDAV\",\"PeriodicalId\":16091,\"journal\":{\"name\":\"Journal of Experimental and Integrative Medicine\",\"volume\":\"10 1\",\"pages\":\"85-88\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Experimental and Integrative Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5455/JEIM.140414.BR.022\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Experimental and Integrative Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/JEIM.140414.BR.022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Vigna unguiculata reduces aortic intima-media thickness and increases aortic diameter and angiogenesis in ovariectomized rats
Objective: This study aimed to determine whether Vigna unguiculata is able to affect aortic intima media thickness, aortic diameter and aortic VEGF expression among ovariectomized rats. Methods: Thirty female rats were divided into 5 groups (n = 6 each) including 1 control group (sham), one ovariectomized (OVX) group, and three test groups. The test rats were OVX group received 0.5 mg/kg body weight (BW), 2.5 mg/kg BW and 5 mg/kg BW of Vigna unguiculata extract. Aortic intima-media thickness was analyzed histologically. Aortic diameter was analyzed in abdominal aorta using ultrasonography. Aortic VEGF expression was analyzed immunohistochemically. Results: OVX decreased the aortic VEGF expression which was significantly elevated by the 5 mg/kg dose of V.unguiculata. OVX also significantly increased aortic intima-media thickness. This increase significantly reversed by the 5 mg/kg dose of the extract. In addition, the aortic diameter in OVX rats was significantly elevated by the 2.5 and 5 mg/kg doses of V.unguiculata extract. Conclusion: Vigna unguiculata extract elevated the decreased angiogenesis and aortic diameter in ovariectomized rats. Besides, the extract also decreased the aortic intima-media thickness. These results provide an alternative natural therapy for vascular pathology in the used experimental model. ©� 2014 GESDAV