Sigal Ben-Zaken , Yoav Meckel , Liina Remmel , Dan Nemet , Jaak Jürimäe , Alon Eliakim
{"title":"十项全能运动员中IGF-I轴基因多态性的患病率","authors":"Sigal Ben-Zaken , Yoav Meckel , Liina Remmel , Dan Nemet , Jaak Jürimäe , Alon Eliakim","doi":"10.1016/j.ghir.2022.101468","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Decathlon is a combined track and field competition, consisting of ten, mainly anaerobic events. Insulin-like growth factor-I (IGF1) axis plays a pivotal role in athletes' structural and functional muscle adaptation to exercise training, and in their competitive performance. Based on the great demand for speed physiological characteristics among decathlon athletes, the aim of this study was to assess the prevalence of IGF genetic polymorphisms<span> among decathletes, to present an optimal genetic profile for enhancing performance.</span></p></div><div><h3>Methods</h3><p>The participants included 151 male athletes and 75 male non-athletic controls from Israel and Estonia. Athletes were divided into four groups, according to the field of expertise: (a) 40 sprinters and long jumpers; (b) 40 middle distance runners; (c) 44 Weightlifters; and (d) 27 decathletes. Genomic DNA was extracted from the participants' buccal epithelial cells using standard protocol and then analyzed for IGF1 axis related genetic polymorphism using the allelic discrimination assay.</p></div><div><h3>Results</h3><p>A significantly higher prevalence of the <em>IGF1</em> rs35767 TT genotype was found among decathletes compared to the other athletes, as well as a lower prevalence of the <em>IGF1</em> rs7136446 GG genotype, a higher prevalence of the <em>IGF1R</em> rs1464430 AA genotype, and a higher prevalence of the <em>IGF2</em> rs680 GG genotype. Moreover, among the decathletes, carriers of the <em>IGF1</em> rs7136446 GG genotype achieved higher decathlon scores compared to A-allele carriers.</p></div><div><h3>Conclusions</h3><p>The findings of this study suggest a potential beneficial role for some IGF-axis polymorphisms (mainly the <em>IGF1</em> 1245 TT and the <em>IGF2</em> GG) among decathletes, both of which are associated with improved speed performance.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"The prevalence of IGF-I axis genetic polymorphisms among decathlon athletes\",\"authors\":\"Sigal Ben-Zaken , Yoav Meckel , Liina Remmel , Dan Nemet , Jaak Jürimäe , Alon Eliakim\",\"doi\":\"10.1016/j.ghir.2022.101468\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Decathlon is a combined track and field competition, consisting of ten, mainly anaerobic events. Insulin-like growth factor-I (IGF1) axis plays a pivotal role in athletes' structural and functional muscle adaptation to exercise training, and in their competitive performance. Based on the great demand for speed physiological characteristics among decathlon athletes, the aim of this study was to assess the prevalence of IGF genetic polymorphisms<span> among decathletes, to present an optimal genetic profile for enhancing performance.</span></p></div><div><h3>Methods</h3><p>The participants included 151 male athletes and 75 male non-athletic controls from Israel and Estonia. Athletes were divided into four groups, according to the field of expertise: (a) 40 sprinters and long jumpers; (b) 40 middle distance runners; (c) 44 Weightlifters; and (d) 27 decathletes. Genomic DNA was extracted from the participants' buccal epithelial cells using standard protocol and then analyzed for IGF1 axis related genetic polymorphism using the allelic discrimination assay.</p></div><div><h3>Results</h3><p>A significantly higher prevalence of the <em>IGF1</em> rs35767 TT genotype was found among decathletes compared to the other athletes, as well as a lower prevalence of the <em>IGF1</em> rs7136446 GG genotype, a higher prevalence of the <em>IGF1R</em> rs1464430 AA genotype, and a higher prevalence of the <em>IGF2</em> rs680 GG genotype. Moreover, among the decathletes, carriers of the <em>IGF1</em> rs7136446 GG genotype achieved higher decathlon scores compared to A-allele carriers.</p></div><div><h3>Conclusions</h3><p>The findings of this study suggest a potential beneficial role for some IGF-axis polymorphisms (mainly the <em>IGF1</em> 1245 TT and the <em>IGF2</em> GG) among decathletes, both of which are associated with improved speed performance.</p></div>\",\"PeriodicalId\":12803,\"journal\":{\"name\":\"Growth Hormone & Igf Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2022-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Growth Hormone & Igf Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1096637422000259\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Hormone & Igf Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1096637422000259","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
The prevalence of IGF-I axis genetic polymorphisms among decathlon athletes
Objective
Decathlon is a combined track and field competition, consisting of ten, mainly anaerobic events. Insulin-like growth factor-I (IGF1) axis plays a pivotal role in athletes' structural and functional muscle adaptation to exercise training, and in their competitive performance. Based on the great demand for speed physiological characteristics among decathlon athletes, the aim of this study was to assess the prevalence of IGF genetic polymorphisms among decathletes, to present an optimal genetic profile for enhancing performance.
Methods
The participants included 151 male athletes and 75 male non-athletic controls from Israel and Estonia. Athletes were divided into four groups, according to the field of expertise: (a) 40 sprinters and long jumpers; (b) 40 middle distance runners; (c) 44 Weightlifters; and (d) 27 decathletes. Genomic DNA was extracted from the participants' buccal epithelial cells using standard protocol and then analyzed for IGF1 axis related genetic polymorphism using the allelic discrimination assay.
Results
A significantly higher prevalence of the IGF1 rs35767 TT genotype was found among decathletes compared to the other athletes, as well as a lower prevalence of the IGF1 rs7136446 GG genotype, a higher prevalence of the IGF1R rs1464430 AA genotype, and a higher prevalence of the IGF2 rs680 GG genotype. Moreover, among the decathletes, carriers of the IGF1 rs7136446 GG genotype achieved higher decathlon scores compared to A-allele carriers.
Conclusions
The findings of this study suggest a potential beneficial role for some IGF-axis polymorphisms (mainly the IGF1 1245 TT and the IGF2 GG) among decathletes, both of which are associated with improved speed performance.
期刊介绍:
Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.