十项全能运动员中IGF-I轴基因多态性的患病率

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2022-06-01 DOI:10.1016/j.ghir.2022.101468
Sigal Ben-Zaken , Yoav Meckel , Liina Remmel , Dan Nemet , Jaak Jürimäe , Alon Eliakim
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引用次数: 1

摘要

十项全能是一项综合田径比赛,由十个主要无氧项目组成。胰岛素样生长因子- 1 (IGF1)轴在运动员肌肉对运动训练的结构和功能适应以及竞技表现中起着关键作用。基于十项全能运动员对速度生理特征的巨大需求,本研究的目的是评估十项全能运动员中IGF基因多态性的患病率,以提出提高成绩的最佳基因谱。方法研究对象为来自以色列和爱沙尼亚的151名男性运动员和75名非运动员。运动员按专业领域分为四组:(a) 40名短跑和跳远运动员;(b) 40名中长跑运动员;(c)举重运动员44名;(d) 27名十项运动员。采用标准方案提取受试者颊上皮细胞的基因组DNA,然后采用等位基因鉴别法分析IGF1轴相关基因多态性。结果十项运动员中IGF1 rs35767 TT基因型的患病率明显高于其他运动员,IGF1 rs7136446 GG基因型的患病率较低,IGF1R rs1464430 AA基因型的患病率较高,IGF2 rs680 GG基因型的患病率较高。此外,在十项全能运动员中,IGF1 rs7136446 GG基因型携带者比a等位基因携带者获得更高的十项全能得分。本研究的结果表明,在十项运动员中,一些igf轴多态性(主要是IGF1 1245 TT和IGF2 GG)具有潜在的有益作用,这两种多态性都与速度表现的提高有关。
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The prevalence of IGF-I axis genetic polymorphisms among decathlon athletes

Objective

Decathlon is a combined track and field competition, consisting of ten, mainly anaerobic events. Insulin-like growth factor-I (IGF1) axis plays a pivotal role in athletes' structural and functional muscle adaptation to exercise training, and in their competitive performance. Based on the great demand for speed physiological characteristics among decathlon athletes, the aim of this study was to assess the prevalence of IGF genetic polymorphisms among decathletes, to present an optimal genetic profile for enhancing performance.

Methods

The participants included 151 male athletes and 75 male non-athletic controls from Israel and Estonia. Athletes were divided into four groups, according to the field of expertise: (a) 40 sprinters and long jumpers; (b) 40 middle distance runners; (c) 44 Weightlifters; and (d) 27 decathletes. Genomic DNA was extracted from the participants' buccal epithelial cells using standard protocol and then analyzed for IGF1 axis related genetic polymorphism using the allelic discrimination assay.

Results

A significantly higher prevalence of the IGF1 rs35767 TT genotype was found among decathletes compared to the other athletes, as well as a lower prevalence of the IGF1 rs7136446 GG genotype, a higher prevalence of the IGF1R rs1464430 AA genotype, and a higher prevalence of the IGF2 rs680 GG genotype. Moreover, among the decathletes, carriers of the IGF1 rs7136446 GG genotype achieved higher decathlon scores compared to A-allele carriers.

Conclusions

The findings of this study suggest a potential beneficial role for some IGF-axis polymorphisms (mainly the IGF1 1245 TT and the IGF2 GG) among decathletes, both of which are associated with improved speed performance.

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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
期刊最新文献
Editorial Board Association of rs35767 polymorphism in the IGF1 gene with athletic performance in power and endurance sports: A meta-analysis The association between change in temporal muscle mass and treatment of acromegaly Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular disease Editorial Board
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