Short-Term Treatment With Ranolazine Improves Mechanical Efficiency in Dogs With Chronic Heart Failure

The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (M&OV0312;o2) and thus improves LV mechanical efficiency in dogs with heart failure (HF). Ranolazine did not change M&OV0312;o2 and LV mechanical efficiency increased (22.4±2.8% to 30.9±3.4% (P <0.05). In contrast, dobutamine significantly increased M&OV0312;o2 and did not improve mechanical efficiency. Thus, short-term treatment with ranolazine improved LV function without an increase in M&OV0312;o2, resulting in an increased myocardial mechanical efficiency in dogs with HF.