Prevention of subinvolution of the uterus of cows using acidum succinicum

Aim. To establish the effect of acidum succinicum on the activity of enzymes in the blood of cows after calving and the course of uterine involution. Materials and Methods. The study of enzyme activity was carried out in the Central Research Laboratory of I. Horbachevsky Ternopil National Medical University (Certificate of technical competence № 001/18, issued on September 26, 2018, valid until September 25, 2023). Results of the research. After the use of acidum succinicum in the body of cows of the experimental group, the activity of alanine aminotransferase increased by 12,0 % (p≤0,05), and the activity of aspartate aminotransferase, on the contrary, decreased by 30,0 % (p≤0,001), which indicates a positive effect on hepatocytes. Confirmation of this is the Ritis factor, which increased 1,4 times (p≤0,05). All animal experiments were conducted according to with the recommendations of ARRIVE and the British Animal Act 1986 and Directive 2010/63 / EU on the protection of animals for scientific investigation. In the body of cows of the control group, the activity of alanine and aspartateaminotransferases increased, respectively, by 14,0 % (p≤0,05) and 47,0 % (p≤0,001) against a background of a 1,2-fold decrease (p≤0,05) Ritis factor. A decrease in bilirubin content of 56,0 % (p≤0,001) in the body of cows after the use of acidum succinicum and an increase in its content by 2,2 times (p≤0,001) in the body of control cows indicates liver disease, which is accompanied by affection of its parenchyma, which may be a consequence of intoxication of their body in the last trimester of pregnancy. Conclusion. Acidum succinicum, applied to cows after calving, prevents the development of inflammation of the reproductive system, helps to restore reproductive function, reduces the duration of the service period to 80,0±2,0 days, and the insemination index to 1,3