环状rna在肿瘤微环境中的新作用

Liang Yu, Yi Xu
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引用次数: 0

摘要

肿瘤微环境(tumor microenvironment, TME)是肿瘤不可缺少的组成部分,是肿瘤细胞与邻近细胞和非癌成分交流的港湾,决定肿瘤的进展。研究人员越来越多地将注意力从肿瘤细胞本身转向动态和复杂的肿瘤微环境,以获得对恶性肿瘤更深入的了解。TME的主动串扰及其异质性使得其特征难以揭示,而其调控机制的细节尚不清楚。对TME重塑的深入了解可能为加强肿瘤治疗提供潜在的生物标志物和治疗靶点。环状rna (circRNAs)是非编码rna的亚群,具有独特的特征和广泛的生物学特性,参与肿瘤的发生和转移。越来越多的证据表明circRNAs具有异常表达并介导信号通路。它们在人类恶性肿瘤事件中发挥着各种作用,如血管生成、免疫逃逸等。circrna在TME中的作用不容忽视,这可能为阐明TME重塑的潜在调控机制提供了新的途径。本文综述了TME和circrna的历史及其在TME中的作用和活性。
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Emerging Roles of CircRNAs in Tumor Microenvironment
The tumor microenvironment (TME) is an integral part of cancer that serves as a harbor where tumor cells com-municate with neighboring cells and non-cancerous components to determine the progression of the tumor. Researchers are increasingly turning their focus away from tumor cells alone and toward the dynamic and intricate tumor microenvironment to acquire a stronger insight into malignancies. The active crosstalk on TME and its heterogeneity make it challenging to reveal its characteristics, while details of the regulatory mechanisms remain unknown. A deep understanding of TME remodeling may provide potential biomarkers and treatment targets to enhance tumor therapy. Circular RNAs (circRNAs) are subpopulations of noncoding RNAs with unique characteristics and a wide range of biological properties involved in tumorigenesis and metastasis. Accumulating evidence has shown that circRNAs have abnormal expression and mediate signaling pathways. They play various roles in human malignancy events, such as angiogenesis, immune escape, and others. The role of circRNAs in the TME cannot be ignored, which may provide a novel path to elucidate the underlying regulatory mechanisms of TME remodeling. This review summarizes the history of TME and circRNAs and their roles and activities in the TME.
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