用离子标记的有机催化剂催化对硝基烯醛的Michael加成

Central European Journal of Chemistry Pub Date : 2014-03-01 DOI:10.2478/s11532-013-0391-4

R. Šebesta, Attila Latika

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引用次数: 6

摘要

抗选择性有机催化Michael添加物为许多生物和医学相关化合物提供了有用的构建块。离子标记的二苯基脯氨醇硅基醚在离子液体中有效催化几种醛对硝基烯的Michael加成。迈克尔加法在离子液体中很有效;产率达95%，对映选择性达95%。此外，在某些情况下，催化系统可重复使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Enantioselective Michael additions of aldehydes to nitroalkenes catalyzed with ionically tagged organocatalyst

AbstractEnantioselective organocatalytic Michael additions affords useful building blocks for many biologically and medicinally relevant compounds. Ionically-tagged diphenylprolinol silyl ether efficiently catalyzes several Michael additions of aldehydes to nitroalkenes in ionic liquids. The Michael additions work well in ionic liquids; yields up to 95% and enantioselectivities up to 95% ee were achieved. Furthermore, in some cases, the catalytic system was reusable.

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来源期刊

Central European Journal of Chemistry 化学-化学综合

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0.00%

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审稿时长

3 months