Antimicrobial Peptides Based on Bacterial S1 Protein Sequences as a Potential Alternative to Antibiotics

An original approach to the development of antimicrobial peptides (AMPs) with a new mechanism of action based on directed coaggregation of a peptide with a target protein is proposed. The unique multifunctional bacterial ribosomal protein S1 was chosen as the target protein. The amyloidogenic and antibacterial effects of various peptides synthesized on the basis of S1 ribosomal protein sequences were studied. The results obtained can serve as a basis for the creation of new AMPs against various strains of pathogenic organisms.