{"title":"提高洛匹那韦溶解度的颗粒工程与喷雾干燥工艺设计","authors":"Santosh Dattu Navale, Soubin Roy, Sumit Shivaji Misal, Prafulla Kumar Sethi","doi":"10.46624/ajptr.2021.v11.i5.004","DOIUrl":null,"url":null,"abstract":"To improve the solubility enhancement of solid dispersion of Lopinavir by spray-drying by adding \nthe Soluplus as polymer that is compatible with Lopinavir, was evaluated and the process used for \npreparation of Spray dried solid dispersion was validated and the 1:3 ratio used for preparation of \nsolid dispersion. Dissolution tests were carried out on several spray dried solid dispersion of \nLopinavir and physical mixture. The solid dispersion characterized by DSC, XRD, % Entrapment \nEfficiency, solubility study, drug content determination, practical yield, dissolution studies. \nKeyword: Lopinavir, Soluplus, Spray Drying Technique, Dissolution studies","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":"27 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Particle Engineering and Spray Drying Process designing for Solubility Enhancement of Lopinavir\",\"authors\":\"Santosh Dattu Navale, Soubin Roy, Sumit Shivaji Misal, Prafulla Kumar Sethi\",\"doi\":\"10.46624/ajptr.2021.v11.i5.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To improve the solubility enhancement of solid dispersion of Lopinavir by spray-drying by adding \\nthe Soluplus as polymer that is compatible with Lopinavir, was evaluated and the process used for \\npreparation of Spray dried solid dispersion was validated and the 1:3 ratio used for preparation of \\nsolid dispersion. Dissolution tests were carried out on several spray dried solid dispersion of \\nLopinavir and physical mixture. The solid dispersion characterized by DSC, XRD, % Entrapment \\nEfficiency, solubility study, drug content determination, practical yield, dissolution studies. \\nKeyword: Lopinavir, Soluplus, Spray Drying Technique, Dissolution studies\",\"PeriodicalId\":7701,\"journal\":{\"name\":\"American Journal of PharmTech Research\",\"volume\":\"27 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of PharmTech Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46624/ajptr.2021.v11.i5.004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of PharmTech Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46624/ajptr.2021.v11.i5.004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Particle Engineering and Spray Drying Process designing for Solubility Enhancement of Lopinavir
To improve the solubility enhancement of solid dispersion of Lopinavir by spray-drying by adding
the Soluplus as polymer that is compatible with Lopinavir, was evaluated and the process used for
preparation of Spray dried solid dispersion was validated and the 1:3 ratio used for preparation of
solid dispersion. Dissolution tests were carried out on several spray dried solid dispersion of
Lopinavir and physical mixture. The solid dispersion characterized by DSC, XRD, % Entrapment
Efficiency, solubility study, drug content determination, practical yield, dissolution studies.
Keyword: Lopinavir, Soluplus, Spray Drying Technique, Dissolution studies
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