长期口服纳米银对哺乳动物认知功能的影响

A. Antsiferova, M. Kopaeva, Vyacheslav N Kochkin, P. Kashkarov
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引用次数: 1

摘要

介绍。自二十一世纪初以来,纳米银由于其显著的抗菌、抗病毒和杀真菌性能,已广泛应用于各种工业、医药和制药领域。鉴于对银纳米颗粒的使用需求如此之高,了解其使用的相关潜在风险是非常重要的。材料和方法。在工作过程中,通过仪器中子活化分析的方法,研究了长期口服以聚乙烯吡咯烷酮稳定的34 nm银纳米颗粒为基础的市产膳食补充剂50 μg/d /只对C57Bl/6小鼠认知功能的影响及其在脑内的积累。所使用的膳食补充剂被推荐用于治疗胃肠道感染。结果。研究发现,在给药180天后,银纳米颗粒损害了长期情境记忆,随着时间的推移,大脑中银的含量增加。结论。可能是老鼠大脑中银的积累损害了认知功能。这就造成了长期口服纳米银的风险。
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Effects of long-term oral administration of silver nanoparticles on the cognitive functions of mammals
Introduction. Since the beginning of the XXI century, silver nanoparticles have been widely used in various industries, medicine and pharmaceuticals due to their pronounced antibacterial, antiviral and fungicidal properties. In connection with such a high demand for the use of silver nanoparticles, it is very important to understand the associated potential risks from their use. Materials and methods. In the course of the work, there has been a study of the effects of the long-term oral administration of a commercially produced dietary supplement based on silver nanoparticles with a size of 34 nm and stabilized with polyvinylpyrrolidone in an amount of 50 μg/day/animal on the cognitive functions of C57Bl/6 mice, as well as their accumulation in the brain by the method of instrumental neutron activation analysis. The dietary supplement used is recommended for people as a treatment for gastrointestinal infections. Results. It was found that after 180 days of administration, silver nanoparticles impair long-term contextual memory, and over time, the content of silver in the brain increases. Conclusion. Presumably impaired cognitive function with accumulation of silver in the brains of mice. This poses the risk of prolonged oral use of the silver nanoparticles.
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