{"title":"侵袭性真菌感染的流行病学","authors":"Z. Karakoç","doi":"10.5152/kd.2019.53","DOIUrl":null,"url":null,"abstract":"Invasive fungal infection (IFI) is still one of the leading causes of morbidity and mortality in immunosupressed hosts. Although Candida species are the most common cause of IFIs and Candida albicans still remains the predominant cause of invasive candidiasis, emergence of non-albicans species has increased with the decreasing fluconazole sensitivity in the world. There is also an increase in the incidence of Aspergillus, new species such as Candida auris, and rare moulds. Many factors have likely contributed to this situation including the number of patients with increased immunosuppression and aggressive chemotherapy, increased use of invasive devices and antimicrobial prophylaxis or treatment approaches. Species and resistance distribution of IFI agents can vary between hospitals and even within different units in the same hospital as in the whole world and may vary according to predisposing factors of patients. Due to these reasons, understanding the changing epidemiology of IFIs is important in developing effective therapeutic and prophylactic approaches for these infections expected to increase in the next decade. Klimik Dergisi 2019; 32(Suppl. 2): 118-23.","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Epidemiology of Invasive Fungal Infections\",\"authors\":\"Z. Karakoç\",\"doi\":\"10.5152/kd.2019.53\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Invasive fungal infection (IFI) is still one of the leading causes of morbidity and mortality in immunosupressed hosts. Although Candida species are the most common cause of IFIs and Candida albicans still remains the predominant cause of invasive candidiasis, emergence of non-albicans species has increased with the decreasing fluconazole sensitivity in the world. There is also an increase in the incidence of Aspergillus, new species such as Candida auris, and rare moulds. Many factors have likely contributed to this situation including the number of patients with increased immunosuppression and aggressive chemotherapy, increased use of invasive devices and antimicrobial prophylaxis or treatment approaches. Species and resistance distribution of IFI agents can vary between hospitals and even within different units in the same hospital as in the whole world and may vary according to predisposing factors of patients. Due to these reasons, understanding the changing epidemiology of IFIs is important in developing effective therapeutic and prophylactic approaches for these infections expected to increase in the next decade. Klimik Dergisi 2019; 32(Suppl. 2): 118-23.\",\"PeriodicalId\":17826,\"journal\":{\"name\":\"Klimik Dergisi/Klimik Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Klimik Dergisi/Klimik Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5152/kd.2019.53\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Klimik Dergisi/Klimik Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5152/kd.2019.53","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
侵袭性真菌感染(IFI)仍然是免疫抑制宿主发病和死亡的主要原因之一。虽然念珠菌是ifi的最常见原因,白色念珠菌仍然是侵袭性念珠菌病的主要原因,但随着世界上氟康唑敏感性的降低,非白色念珠菌的出现也在增加。曲霉、新菌种如耳念珠菌和稀有霉菌的发病率也有所增加。许多因素可能导致这种情况,包括免疫抑制和积极化疗增加的患者数量,侵入性设备和抗菌预防或治疗方法的使用增加。IFI药物的种类和耐药分布在不同医院之间,甚至在同一医院的不同单位内,甚至在全世界,都可能有所不同,并可能根据患者的易感因素而有所不同。由于这些原因,了解ifi不断变化的流行病学对于制定有效的治疗和预防方法至关重要,这些感染预计将在未来十年增加。Klimik Dergisi 2019;32(5。2): 118 - 23所示。
Invasive fungal infection (IFI) is still one of the leading causes of morbidity and mortality in immunosupressed hosts. Although Candida species are the most common cause of IFIs and Candida albicans still remains the predominant cause of invasive candidiasis, emergence of non-albicans species has increased with the decreasing fluconazole sensitivity in the world. There is also an increase in the incidence of Aspergillus, new species such as Candida auris, and rare moulds. Many factors have likely contributed to this situation including the number of patients with increased immunosuppression and aggressive chemotherapy, increased use of invasive devices and antimicrobial prophylaxis or treatment approaches. Species and resistance distribution of IFI agents can vary between hospitals and even within different units in the same hospital as in the whole world and may vary according to predisposing factors of patients. Due to these reasons, understanding the changing epidemiology of IFIs is important in developing effective therapeutic and prophylactic approaches for these infections expected to increase in the next decade. Klimik Dergisi 2019; 32(Suppl. 2): 118-23.