地方性甲状腺肿区偶发的甲状腺乳头状小癌

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM Journal of Thyroid Research Pub Date : 2016-02-02 DOI:10.1155/2016/1784397
E. Gürleyik, G. Gurleyik, B. Karapolat, U. Onsal
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引用次数: 10

摘要

随访102个月,研究偶发甲状腺乳头状微癌的临床病理特点、手术、内科及核治疗方法及患者预后。我们研究了37例偶发甲状腺乳头状微癌(I-PTM)。手术方式为全甲状腺切除术29例,半甲状腺切除术8例。PTM病灶的大小、多灶性和双侧性、甲状腺囊浸润和淋巴血管浸润是组织病理学参数。我们分析了102(61-144)个月的随访期间的辅助医疗和核治疗以及患者的预后。395例甲状腺切除术患者中I-PTM患病率为9.4%。组织病理学检查报告30例为单灶性疾病,7例为多灶性疾病(18%)。6例(20.1%)为多灶性双侧病变。PTM病灶的平均大小为4.88 mm。甲状腺包膜侵犯率为5.4%。所有患者均接受抑制剂量的LT4以达到低血清TSH水平。我们的病例没有进行辅助手术和核治疗。我们没有发现任何血液化学和超声成像的负面变化,以及任何不利的事件,如局部和全身复发。总之,I-PTM的诊断是常见的,多灶性和双侧表现为病理特征。经手术治疗及抑制TSH后预后良好。常规辅助核治疗在大多数患者中是不必要的。
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Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area
Clinical and pathological characteristics of incidental papillary thyroid microcancer cases, surgical, medical, and nuclear treatment methods, and patients' outcome were studied during follow-up period of 102 months. We studied 37 patients with incidental papillary thyroid microcancer (I-PTM). The surgical procedure was total thyroidectomy in 29 and hemithyroidectomy in 8 patients. Size, multifocality, and bilateralism of PTM foci, thyroid capsule invasion, and presence of lymphovascular invasion were histopathological parameters. We analysed adjuvant medical and nuclear treatment and patients' outcome during follow-up period of 102 (61–144) months. The prevalence rates of I-PTM were 9.4% in 395 thyroidectomy cases. Histopathological examination reported unifocal disease in 30 and multifocal disease in 7 (18%) patients. Multifocal disease was bilateral in 6 (20.1%) patients. The mean size of the PTM foci was 4.88 mm. The rate of thyroid capsule invasion was 5.4%. All patients received a suppressive dose of LT4 to achieve a low serum TSH level. Adjuvant surgical and nuclear treatment was not performed in our cases. We did not find any negative changes in blood chemistry and ultrasound imaging, and any unfavourable events as locoregional and systemic recurrence. In conclusion, diagnosis of I-PTM is common that multifocality and bilateralism appear as pathologic features. The prognosis is excellent after surgical treatment and TSH suppression. Routine adjuvant nuclear treatment is unnecessary in majority of patients.
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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
期刊最新文献
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