8周间歇训练对甲基苯丙胺依赖大鼠海马组织淀粉样前体蛋白(APP)基因表达的影响(晶体)

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摘要

简介:甲基苯丙胺(冰毒)是一种兴奋剂,会导致记忆和学习障碍。本研究旨在探讨8周间歇训练对甲基苯丙胺依赖大鼠海马组织APP基因表达和开放场试验的影响。方法:将32只大鼠随机分为生理盐水、甲基苯丙胺(METH-1)、甲基苯丙胺+训练(METH+MIT)和甲基苯丙胺(METH-2) 4组。注射剂量为5 mg/kg体重,连续注射21天。锻炼计划(每周5次)包括在跑步机上进行间歇训练(4组,每组4分钟,强度适中,每组之间休息2分钟)。在注射和训练结束时,提取大鼠海马组织,评估基因表达变化。还进行了野外行为测试。数据分析采用单因素方差分析,显著性水平P≥0.05。结果:甲基苯丙胺与生理盐水(分别;P≥0.007和P≥0.005)。与生理盐水相比,METH-1、meth - 2组大鼠总距离和运动速度显著降低(P≥0.004、P≥0.026)。与METH-1、2组相比,MIT导致APP显著降低(P分别≥0.041和P≥0.028)。与METH-1组相比,MIT组的运动速度明显增加(P≥0.008)。结论:甲基苯丙胺降低了认知表现(学习和记忆),根据结果,MIT可能改善了认知表现。尽管如此,需要进一步的研究才能得出明确的结论。
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Effect of Eight Weeks of Interval Training on Amyloid Precursor Protein (APP) Gene Expression in Hippocampal Tissue in Methamphetamine-dependent Rats (Crystal)
Introduction: Methamphetamine (METH) is a stimulant drug that causes memory and learning disorders. The present study aimed to investigate the effect of eight weeks of interval training on APP gene expression in hippocampal tissue and open field test in methamphetamine-dependent rats. Method: In this experimental research, 32 rats were assigned to four equal groups of saline, primary methamphetamine (METH-1), methamphetamine+training (METH+MIT), and secondary methamphetamine (METH-2). The METH was injected at the dose of 5 mg/kg body weight for 21 days. The exercise program (5 sessions per week) included interval training (4 sets of 4 minutes with moderate intensity and 2 minutes of active rest between sets) on a treadmill. At the end of the injection and training period, the hippocampus tissue of the rats was extracted to evaluate gene expression changes. An open-field behavioral test was also conducted. The data were analyzed using the one-way ANOVA at the significance level of P≥0.05. Results: Methamphetamine significantly increased APP gene expression in METH-1,2 groups compared to saline (respectively; P≥0.007 and P≥0.005). The total distance and movement speed of rats in METH-1 and 2 groups had a significant decrease compared to saline (respectively, P≥0.004 and P≥0.026). The MIT led to a significant reduction of APP compared to METH-1,2 groups (respectively, P≥0.041 and P≥0.028). Movement speed in the MIT group increased significantly compared to the METH-1 group (P≥0.008). Conclusion: Methamphetamine reduced cognitive performance (learning and memory), and according to the results, MIT probably improved cognitive performance. Nonetheless, further studies are necessary to reach definitive conclusions.
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