孟加拉国某三级医院D2胃切除术早期术后预后的前瞻性研究

N. Hossain, A. Habib, Q. Habibullah
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摘要

胃切除术和适当的淋巴结切除术被认为是治疗潜在可治愈的胃癌的基石。胃癌是世界范围内癌症相关死亡的主要原因之一。每年,它被诊断为9,89600例新病例和7,38,000例死亡(占全球癌症死亡总数的10%)。总体预后不是很好。然而,胃切除术是唯一有机会长期生存和治愈的治疗方式。研究目的:研究D2胃切除术的早期术后预后。材料与方法:本前瞻性研究于2019年1月至2020年12月在孟加拉国达卡国家癌症研究与医院(NICRH)外科肿瘤科进行。本研究共纳入80例行胃切除术的胃癌患者。采用Epi Info (TM) 7.2.2.2进行统计分析。EPI INFO是美国疾病控制与预防中心(CDC)的商标。采用描述性统计分析计算相应标准差的均值。结果:患者平均年龄(mean±SD)为49.10±8.32岁,年龄范围28 ~ 66岁,中位年龄为48.5岁。45 ~ 54岁年龄组(50.0%)显著高于其他年龄组(Z= 3.26;p < 0.001)。年龄在25-34岁之间的患者占5.0%,年龄≥55岁的患者占27.5%。因此,在本研究中,年龄在之间的患者患胃癌的风险较高。男性占比(75.0%)显著高于女性(25.0%)(Z=7.07;p < 0.0001)。结论:在多种肿瘤治疗模式中,手术治疗是胃癌治愈或长期生存的唯一希望。它通过局部控制提供快速的症状缓解,增加个体的生存,在早期胃癌的情况下治愈和适当的分期,以规划后续的辅助治疗。
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A Prospective Study of Early Postoperative Outcome of D2 Gastrectomy: A Tertiary Hospital of Bangladesh
Introduction: Gastrectomy with proper lymphadenectomy is considered the cornerstone of treatment for potentially curable gastric cancer. Stomach cancer is one of the important leading causes of cancer related death in worldwide. Annually, it was diagnosed with 9, 89,600 new cases and 7, 38,000 deaths (10% of all cancer death) in worldwide. The overall prognosis is not very favorable. However, surgery in the form of gastrectomy is the only treatment modality for a chance of long term survival as well as hope for cure. Aim of the study: Aim of the study was to find outcome of Early Postoperative Outcome of D2 Gastrectomy. Material & Methods: This prospective study was conducted at the Department of Surgical Oncology, National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh from January 2019 to December 2020. A total 80 number of gastric cancer patients who were underwent gastrectomy were considered in this study. Statistical Analysis was performed with help of Epi Info (TM) 7.2.2.2. EPI INFO is a trademark of the Centers for Disease Control and Prevention (CDC). Descriptive statistical analysis was performed to calculate the means with corresponding standard deviations. Results: The mean age (mean ± SD) of the patients was 49.10±8.32 years with range 28-66 years and the median age was 48.5 years. The age group 45-54 years (50.0%) were significantly higher than other age group (Z= 3.26; p<0.001). Only 5.0% were with age between 25-34 years and 27.5% of the patients were with age ≥55 years. Thus in this study the patients with age between were in higher risk of having gastric cancer. Proportion of males (75.0%) was significantly higher than that of females (25.0%) (Z=7.07; p<0.0001). Conclusion: Surgery for gastric cancer is the only hope for cure or long term survival in the arena of multimodal management of cancers. It provides quick symptom relief by loco regional control, adds to survival of the individual, cure in case of early gastric cancer and proper staging for planning of subsequent adjuvant treatment.
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