比较高强度间歇训练(HIIT)与高强度连续训练(HICT)两种方法对雄性Wistar大鼠肝脏损伤及抗氧化指标的影响

A. Ghasemnian, Mozhgan Usefpour, A. Rahmani, Zeinab Iddehloei
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摘要

背景:高强度间歇训练(HIIT)是目前广泛应用的一种训练方法。此外,研究人员指出,长期、高强度的训练与体内自由基的产生有关。自由基也会损害肝细胞,导致肝酶增加。目的:本研究的目的是探讨HIIT与高强度连续训练(HICT)相比对雄性Wistar大鼠肝脏损伤和抗氧化指标的影响。方法:将22只成年雄性大鼠随机分为对照组(n = 6)、HIIT组(n = 8)和HICT组(n = 8)。训练方案包括HIIT和HICT在跑步机上进行8周(每周5天)。给大鼠随意提供标准水和食物。最后一次训练结束48小时后,采集血液和组织样本,按照国际临床化学和检验医学联合会(IFCC)推荐的方法测定血清酶。肝组织超氧化物歧化酶活性水平采用Randox商用试剂盒(Cat。不。SD 126)。采用单因素方差分析(ANOVA)和Tukey事后检验对数据进行分析。结果:8周HIIT和HICT对血清谷丙转氨酶(ALT)水平无影响(P = 0.14),但HIIT 8周显著降低血清谷草转氨酶(AST)水平(P = 0.04)。与对照组相比,HIIT组和HICT组肝脏超氧化物歧化酶(SOD)酶活性水平显著升高(P = 0.001)。与HIIT相比,HICT组SOD水平也显著升高(P = 0.03)。结论:研究结果表明,HIIT 8周可显著降低血清AST水平,且HIIT对肝组织SOD活性升高的影响低于HICT。可以说HIIT比HICT更安全,对肝组织的破坏作用更小。
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Comparing the Effect of Two Methods of High-Intensity Interval Training (HIIT) and High-Intensity Continuous Training (HICT) on Damage and Antioxidant Indices of Liver in Male Wistar Rats
Background: Nowadays, one of the widely used training methods is high-intensity interval training (HIIT). In addition, researchers have stated that long-term, high-intensity training is associated with the production of free radicals in the body. Free radicals also damage liver cells, resulting in increased liver enzymes. Objectives: The objective of this study was to investigate the effect of HIIT, compared to high-intensity continuous training (HICT), on damage and antioxidant indices of the liver in male Wistar rats. Methods: Twenty-two adult male rats were randomly divided into three groups of control (n = 6), HIIT (n = 8), and HICT (n = 8). Training protocols included HIIT and HICT on a treadmill for eight weeks (five days in a week). Standard water and food were provided for rats ad libitum. Forty-eight hours after the last training session, blood and tissue samples were collected, and serum enzymes were measured by the methods recommended by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) method. The level of enzyme activity of superoxide dismutase in the liver tissue was measured by Randox Commercial Kit (Cat. No. SD 126). One-way analysis of variance (ANOVA) and Tukey’s post hoc tests were used to analyze the data. Results: The results showed that eight weeks of HIIT and HICT had no effect on the alanine aminotransferase (ALT) level (P = 0.14), but eight weeks of HIIT significantly decreased the serum aspartate aminotransferase (AST) level compared to the control group (P = 0.04). The level of liver superoxide dismutase (SOD) enzyme activity significantly increased in the HIIT and HICT groups compared to the control group (P = 0.001). HICT also led to a significant increase in the SOD level compared to HIIT (P = 0.03). Conclusions: The research results suggested that eight weeks of HIIT led to a significant reduction in serum AST levels, and HIIT had a lower effect on the increased SOD activity in liver tissue compared to HICT. It might be stated that HIIT is safer than HICT, and it has fewer destructive effects on liver tissue.
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