合成,抗氧化剂和抗癌化合物活动试验3′,4′-DIMETHOXY FLAVONOL

Muhamad Rokim
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引用次数: 0

摘要

以3,4-二甲氧基-2 ' -羟基查尔酮为原料,在碱性条件下合成了3 ',4 ' -二甲氧基黄酮醇。利用高效液相色谱和紫外、红外、核磁共振、质谱等光谱数据对化合物的结构进行了表征。DPPH法测定了黄酮醇的抗氧化活性,MTS法测定了黄酮醇的抗癌活性,结果表明,3′,4′-二甲氧基黄酮醇具有抗氧化活性,但抗癌活性较弱。
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SINTESIS, UJI AKTIVITAS ANTIOKSIDAN DAN ANTIKANKER SENYAWA 3′,4′-DIMETHOXY FLAVONOL
3′,4′-dimethoxy flavonol have been synthesized from 3,4-dimethoxy-2’-hydroxychalcon under basic condition (KOH). The structures of all compounds were characterized based on the interpretation of HPLC chromatorgrams and spectroscopic data including UV, FTIR, NMR and HRMS. Antioxidant activity was evaluated using the DPPH assay and anticancer activity was evaluated using the MTS assay which showed that the 3′,4′-dimethoxy flavonol was active as antioxidants and weak anticancer activity.
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