纳米尺度药物传递的综合理论研究

Rq Sofi, S. Majeed, A. Sofi
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引用次数: 0

摘要

纳米技术是一门集物理、化学、生物学等学科于一体的跨学科科学,涉及在纳米尺度上创造和利用材料、器件或系统,目前在许多方面正经历着意想不到的发展。它在材料强化和制造、医疗保健、农业、食品加工和储存、人类福利机器人、能源节约和利用、运输、制造安全和优质产品以及全球层面的安全方面有许多应用[1-11]。此外,这些无与伦比的应用具有令人难以置信的潜力,可以彻底改变所有技术领域,并有望在各种生物医学应用中创造创新并发挥重要作用,如药物输送系统、分子成像、生物标志物、治疗学、诊断学、癌症治疗、生物传感器等。良性合成和有序给药系统的建立对医疗卫生具有重要意义。在这一领域,纳米给药系统,特别是纳米颗粒已经发展出了巨大的改进,为克服传统给药方法的障碍和缺陷提供了新的机会,如提高药物的溶解度,降低药物毒性,屏蔽药物变质,将药物无效和良性地递送到体内特定靶点等[12-15]。
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A Comprehensive Theoretical Study of Drug Delivery at Nanoscale
Nanotechnology, an interdisciplinary science that incorporates physics, chemistry, biology, etc. involves creation and utilization of materials, devices or systems on the nanometer scale and is currently undergoing unexpected development on many fronts. It finds numerous applications in material strengthening and fabrication, healthcare, agriculture, processing and storage of foods, robotics for human welfare, energy conservation and utilization, transport, manufacturing of safe and quality products and security at global level [1-11]. Besides, these unparalleled applications it has incredible potential for revolutionizing all fields of technology and is expected to create innovations and play a vital role in various biomedical applications like, drug delivery systems, molecular imaging, biomarkers, therapeutics, diagnostics, cancer therapy, biosensors, etc. Synthesis via benign route and building of orderly drug delivery systems are very important for medical and health-care. In this field, nano-based drug delivery system specifically nanoparticles have developed a great modification that provides new opportunities to move over hindrances and flaws of conventional drug delivery methods like enhance solubility of drugs, diminish drug toxicity, beshields drugs from deterioration, ineffective and benign delivery of drugs to specific target sites in the body, etc. [12-15].
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