论肿瘤治疗领域的改进

IF 1 Q4 ENGINEERING, BIOMEDICAL AIMS Bioengineering Pub Date : 2023-01-01 DOI:10.3934/bioeng.2023002
M. Fioranelli, A. Sepehri
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引用次数: 0

摘要

最近的研究表明,电磁波的特殊频率和强度可以控制某些类型细胞的分化。利用这一事实,肿瘤治疗场(TTFields)疗法被提出作为一种技术,它使用中频(~ 100-500 kHz)和低强度(1-3 V/cm)的交变电场来破坏肿瘤的细胞分裂。然而,这种技术可能会对正常细胞周围的离子液体产生有害影响。例如,电极可以在血管内产生额外的电流。为了观察这些效果,我们将电极连接到含有水和一些额外离子的载玻片上,并将它们放在1000倍显微镜下。我们发现一些离子、微生物和细胞向负电子移动,而一些则离开。这些被电极吸引的细胞可能会导致大脑的破坏。我们还发现液体中出现了一些电流,这些电流吸收或排斥水分子并产生一些气泡。如果这些类型的气泡出现在血管内,它们可以对正常细胞的膜施加压力并破坏它们。为了避免这些问题,我们建议用一些发射特殊频率的电磁发送器/接收器代替电极。这些频率只能被肿瘤周围的血管吸收,因为这些血管可能只是为肿瘤细胞提供所需的食物,因此与正常细胞周围的血管相比,它们具有不同的电位和电流。因此,这些肿瘤血管可以作为TTFields的天线。
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A comment to improve tumor-treating fields therapy
Recent investigations have shown that special frequencies and intensities of electromagnetic waves could control the differentiations of some types of cells. Using this fact, tumor-treating fields (TTFields) therapy has been proposed as a technique which uses alternating electric fields of intermediate frequency (~100–500 kHz) and low intensity (1–3 V/cm) to disrupt the cell divisions of tumors. However, this technique may have harmful effects on ionic liquids around normal cells. For example, electrodes could induce an extra electrical current within blood vessels. To observe these effects, we connected electrodes to a slide that includes water and some extra ions and put them under a 1000× microscope. We found that some ions, microbes and cells move toward negative electrons and some go away. These attractions of cells by electrodes could cause the destruction of the brain. We also found some electrical currents within the liquid emerge which absorb or repel water molecules and induce some bubbles. If these types of bubbles arise within the blood vessels, they can exert a force on the membranes of normal cells and destroy them. To avoid these problems, we suggest that electrodes should be replaced by some electromagnetic sender/receiver which emits some special frequencies. These frequencies could be absorbed only by blood vessels around the tumors because these vessels may be created only to provide the needed food for tumor cells and thus have a different potential and electrical current as compared to vessels around normal cells. Thus, these tumor vessels could act as the antenna for TTFields.
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来源期刊
AIMS Bioengineering
AIMS Bioengineering ENGINEERING, BIOMEDICAL-
自引率
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发文量
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审稿时长
4 weeks
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