髋关节骨关节炎发生的危险因素和人群归因分数

IF 1.6 4区 医学 Q3 ORTHOPEDICS Hss Journal Pub Date : 2023-08-29 DOI:10.1177/15563316231192461
J. Runhaar, A. C. van Berkel, R. Agricola, J. V. van Meurs, S. Bierma-Zeinstra
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引用次数: 0

摘要

背景:尽管髋关节骨关节炎(OA)负担巨大且缺乏有效治疗,但对髋关节骨关节炎一级预防的研究尚处于起步阶段。目的:我们试图评估中老年成人发生临床和放射学髋关节OA的危险因素,从预防的角度评估危险因素的重要性,并估计归因于这些危险因素的新病例的百分比。方法:我们回顾性地回顾了鹿特丹研究的数据,这是一项55岁或以上个体的开放人群队列研究。随访11年后,分别评估基线年龄、性别、体重指数、吸烟状况、教育水平、糖尿病诊断、c反应蛋白(CRP)、cam形态、髋臼发育不良、x片拇指OA、x片髋关节OA和髋关节疼痛与临床髋关节OA和x片髋关节OA的相关性。计算具有统计学意义的可改变危险因素的人群归因分数(PAFs)。结果:临床新发髋关节骨关节炎占19.9%(2729例中的544例),放射学髋关节骨关节炎发生率为9.9%(3309例中的329例)。女性、教育程度低于平均水平(PAF 21.4%)和x线髋关节OA (PAF 3.4%)与临床髋关节OA的发生有统计学意义。女性性别、年龄、超重(PAF 20.0%)、cam形态(PAF 7.9%)、髋臼发育不良(PAF 3.6%)和拇指骨性关节炎(PAF 4.7%)与髋部骨性关节炎有统计学意义相关。结论:我们的回顾性分析表明,从一级预防的角度来看,中老年个体中最重要的可改变的危险因素可能是临床髋关节OA事件的低教育水平和影像学髋关节OA事件的超重。值得进一步研究。
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Risk Factors and Population-Attributable Fractions for Incident Hip Osteoarthritis
Background: Despite the huge burden of hip osteoarthritis (OA) and the lack of effective treatment, research into the primary prevention of hip OA is in its infancy. Purpose: We sought to evaluate risk factors for incident clinical and incident radiographic hip OA among middle-aged and older adults, to evaluate the importance of risk factors from a preventive perspective, and to estimate the percentage of new cases attributable to these risk factors. Methods: We retrospectively reviewed data from the Rotterdam study, an open-population cohort study of individuals aged 55 years or older. Data including baseline age, sex, body mass index, smoking status, education level, diagnosis of diabetes, C-reactive protein (CRP), cam morphology, acetabular dysplasia, radiographic thumb OA, radiographic hip OA, and hip pain were assessed for their association with incident clinical hip OA and incident radiographic hip OA separately, after 11 years of follow-up. The population-attributable fractions (PAFs) of statistically significant modifiable risk factors were calculated, as well. Results: New onset of clinical hip OA was seen in 19.9% (544 of 2729) and incident radiographic hip OA in 9.9% (329 of 3309). Female sex, education level below average (PAF 21.4%), and radiographic hip OA (PAF 3.4%) were statistically significantly associated with incident clinical hip OA. Female sex, age, overweight (PAF 20.0%), cam morphology (PAF 7.9%), acetabular dysplasia (PAF 3.6%), and radiographic thumb OA (PAF 4.7%) were statistically significantly associated with radiographic hip OA. Conclusions: Our retrospective analysis suggests that, from a primary prevention perspective, the most important modifiable risk factors among middle-aged and older individuals may be low educational level for incident clinical hip OA and overweight for incident radiographic hip OA. Further study is warranted.
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来源期刊
Hss Journal
Hss Journal Medicine-Surgery
CiteScore
3.90
自引率
0.00%
发文量
42
期刊介绍: The HSS Journal is the Musculoskeletal Journal of Hospital for Special Surgery. The aim of the HSS Journal is to promote cutting edge research, clinical pathways, and state-of-the-art techniques that inform and facilitate the continuing education of the orthopaedic and musculoskeletal communities. HSS Journal publishes articles that offer contributions to the advancement of the knowledge of musculoskeletal diseases and encourages submission of manuscripts from all musculoskeletal disciplines.
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