纳米颗粒给药:一种很有前途的蛋白质药物给药方法

P. R. Dhapake, J. Baheti, P. Suruse
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引用次数: 0

摘要

蛋白质药物是由于在胃肠道酸性和富含蛋白酶的环境中蛋白质复合物的降解问题而不能口服给药的生物药物。高分子量的蛋白类药物在口服时往往导致外周吸收不良。因此,蛋白质药物一般通过注射给药。大多数蛋白质药物的血清半衰期较短,需要频繁或大剂量给药才能达到治疗效果。频繁的注射给药会使患者感到不舒服,并且由于药物与非靶向组织的非特异性结合,累积剂量也可能产生严重的副作用。因此,蛋白质类药物在给药方面的这些困难为新型药物递送系统(dds)的研制提供了动力。这种新型药物递送系统使药物在口服给药后不受体内生物和化学降解的影响,并能长时间释放药物。高分子纳米颗粒包裹蛋白质药物是一种被广泛研究的蛋白质药物递送技术。某些配体可增强纳米颗粒穿过肠上皮细胞的渗透,因此配体共轭聚合物可用于增强蛋白质药物穿过肠道的渗透。
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Nanoparticulate Drug Delivery: A Promising Drug Delivery for Protein Drug
Protein drugs are the biological drug which cannot be administered orally due to problems related to degradation of protein complex in the acidic and protease-rich environment of the gastrointestinal (GI) tract. High molecular weight of protein drugs often results in poor absorption into the periphery when administered orally. Thus, generally protein drugs administered by injection. Most of the proteins drug have a short serum half-life which need to be administered frequently or in high doses to achieve the therapeutic effectiveness. Frequent dosing of these drugs by injection make patient uncomfortable and cumulative doses also may produce severe side effect due to unspecific binding of drug to non-targeted tissue. So, these difficulties in the administration of protein drugs provides the motivation for preparation of novel drug delivery systems (DDSs) In which drug will protect form biological and chemical degradation in the body and able to release drug for long time after oral administration. Encapsulation of proteins drug in a polymeric nanoparticle has been a widely investigated technology for protein drug delivery. Some ligand enhances the penetration of nanoparticles across the intestinal epithelial cell thus the ligand conjugated polymer can use to enhance the penetration of protein drug across the intestine.
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