对乙酰氨基酚对控制腹股沟疝手术全麻后寒战的有效剂量

Noemie Schiever, Romina Shahini, R. Shahini
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引用次数: 0

摘要

腹股沟疝是最常见的腹疝类型,男性的发生率是女性的7倍。手术治疗在全身麻醉下进行。40% ~ 60%的术后患者会出现震颤症状。这些患者在麻醉后,颤抖是非常不可取的,从生理方面来说是非常紧张的,轻微的震颤增加了耗氧量,就像轻微的体育活动一样,颤抖使代谢率和耗氧量增加了600%。注射用对乙酰氨基酚是一种安全的药物,最近的研究确定了手术麻醉后控制寒战的有效剂量。目的:探讨注射对乙酰氨基酚对腹股沟疝术后寒战质量和时机的影响。材料与方法:这是一项随机双盲研究,统计人群是在卡兹温医科大学医院接受普通外科治疗的候选者。根据麻醉医师的检测,患者接受了1级和2级全麻手术。在随机选取的80例患者中,选取40人作为实验组,注射对乙酰氨基酚IM注射液0.5 mg/kg, 40人作为安慰剂对照组(常规顺序)。结果:试验组患者寒战次数明显低于对照组,差异有统计学意义。实验组的震颤强度在三个测量指标中均低于对照组[1,2],这对于线性回归的比较也有显著意义,根据数据的正态分布,两组的相对危险度(RR)均为8,在20 ~ 40岁年龄组中观察到震颤的最小范围,在20岁以下年龄组中观察到震颤的最小范围。结论:全身麻醉后注射对乙酰氨基酚(IM)可降低术后寒战次数和严重程度,是腹股沟疝手术患者术后有效的首选药物。
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Effectiveness Dose of Injection Acetaminophen for Control of Shivering After General Anesthesia in Inguinal Hernia Surgery
Introduction: Inguinal hernia is the most common type of abdominal hernia which is 7 times more common in men than women. Surgical treatment is performed under general anesthesia. about 40 to 60 percent of patients of post-surgery are experiencing tremor. these patients after anesthesia, shivering is very undesirable and from the physiological aspect is very stressful, mild tremor increases the oxygen consumption like a light physical activity and judder increases the metabolic rate and oxygen consumption up to 600%. injection acetaminophen is a safe drug, in recent study determines of Effectiveness dose for control of shivering after anesthesia in surgeries. Aim: The aim of this study was to determine the effect of injection acetaminophen on the quality and timing of the Shivering after on the inguinal herniation surgery. Materials and Methods: This is a randomized double-blind study, that the statistical population was patients that were candidates for general surgery, that were referred to hospitals of Qazvin University of Medical Sciences for treatment. The patient’s undergone surgery with general anesthesia with number 1 and 2 anesthetic Class based on anesthesiologist detection. From 80 patients that were randomly selected, 40 people were selected for experimenting group with injection acetaminophen with IM injection of 0.5 mg/kg and 40 people were selected for the placebo control group (routine order). Results: The shivering in the experimenting group was decreased than the control group and was statistically significant. Tremor intensity in the experimental group was lower than the control group in all three measures [1, 2] which was also significant for comparing the linear regression, relative risk (RR) was 8in two groups according to the normal distribution of the data, in the age group between 20to 40 years the minimum range of tremor was observed and in the age group that were younger than 20 years range of tremor was observed. Conclusion: injection acetaminophen (IM) after general anesthesia can reduce the amount and severity of shivering at post-surgery and can be an effective choice drug in the post-surgery in patients with inguinal herniation surgery.
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