Pub Date : 2023-07-03DOI: 10.59657/2837-2565.brs.23.052
Gourav Ganesh, Karuppanagounder Somasundaram
Melanoma cancer has been considered as one of the deadliest cancers. Melanoma is a highly malignant form of skin cancer that originates from melanocytes, the cells responsible for producing skin pigment. It is characterized by the uncontrolled prolife-elation of abnormal cells, which have the potential to invade surrounding tissues and spread to distant parts of the body. In this work, we aim to classify the skin disease into 7 classes. Our objective is to propose a deep learning CNN model to improve the accuracy of melanoma detection by customizing the number of layers in the network architecture and activation functions followed by reducing the computational cost. A comparative study is made between the improved model and the use of pre-trained Models like Resnet, Dense Net, Inception, VGG and Dense Net-II which has been giving impeccable accuracy. The HAM10000 dataset is used for research and we have got better results for the proposed model. Also, graphical results have been obtained for the same.
{"title":"Detect Melanoma Skin Cancer Using an Improved Deep Learning CNN Model with Improved Computational Costs","authors":"Gourav Ganesh, Karuppanagounder Somasundaram","doi":"10.59657/2837-2565.brs.23.052","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.23.052","url":null,"abstract":"Melanoma cancer has been considered as one of the deadliest cancers. Melanoma is a highly malignant form of skin cancer that originates from melanocytes, the cells responsible for producing skin pigment. It is characterized by the uncontrolled prolife-elation of abnormal cells, which have the potential to invade surrounding tissues and spread to distant parts of the body. In this work, we aim to classify the skin disease into 7 classes. Our objective is to propose a deep learning CNN model to improve the accuracy of melanoma detection by customizing the number of layers in the network architecture and activation functions followed by reducing the computational cost. A comparative study is made between the improved model and the use of pre-trained Models like Resnet, Dense Net, Inception, VGG and Dense Net-II which has been giving impeccable accuracy. The HAM10000 dataset is used for research and we have got better results for the proposed model. Also, graphical results have been obtained for the same.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85517027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.59657/2837-2565.brs.23.048
Chiemi Kobayashi, Y. Makihara, Y. Nishida
Aim: This study aimed to identify the factors that significantly affect the quality of life (QoL) of patients with Stiff-Person syndrome (SPS) by examining their physical, psychological, and social aspects using questionnaires. Methods: This cross-sectional study included 23 patients with SPS. Data were collected using several questionnaires. Patient QoL was quantified using the EuroQoL-5-Dimention 5-Level; sociodemographic characteristics and other relevant variables were examined. Results: QoL was poorer for patients with SPS than those with moderate to severe Alzheimer’s disease. Several important factors for patients’ QoL have been identified, including difficulty in breathing, pain, mobility issues leading to difficulty performing daily activities, depressive symptoms inherent to SPS, and insufficient social support. Conclusion: Factors that significantly influenced the QoL of patients with SPS were related to multiple aspects of their lives. We evaluated all previously used methods. A disease-specific evaluation form is required to assess these patients thoroughly.
{"title":"Quality of Life of Patients with Stiff Person Syndrome","authors":"Chiemi Kobayashi, Y. Makihara, Y. Nishida","doi":"10.59657/2837-2565.brs.23.048","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.23.048","url":null,"abstract":"Aim: This study aimed to identify the factors that significantly affect the quality of life (QoL) of patients with Stiff-Person syndrome (SPS) by examining their physical, psychological, and social aspects using questionnaires. Methods: This cross-sectional study included 23 patients with SPS. Data were collected using several questionnaires. Patient QoL was quantified using the EuroQoL-5-Dimention 5-Level; sociodemographic characteristics and other relevant variables were examined. Results: QoL was poorer for patients with SPS than those with moderate to severe Alzheimer’s disease. Several important factors for patients’ QoL have been identified, including difficulty in breathing, pain, mobility issues leading to difficulty performing daily activities, depressive symptoms inherent to SPS, and insufficient social support. Conclusion: Factors that significantly influenced the QoL of patients with SPS were related to multiple aspects of their lives. We evaluated all previously used methods. A disease-specific evaluation form is required to assess these patients thoroughly.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82474940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.59657/2837-2565.brs.23.051
S. Kassa, D. Ayalew
Introduction: Esophageal fibro-vascular polyps (EFVPs) are rare benign tumors that can arise from the submucosa of the esophagus. They are usually asymptomatic but can cause obstruction and dysphagia in some cases. The diagnosis of EFVPs can be challenging due to their rarity and nonspecific symptoms. Delayed diagnosis can result in significant morbidity, as in the case of our patient who suffered from difficulty swallowing for over a decade before being accurately diagnosed. We present a case of a 42-year-old male patient with a 12-year history of difficulty swallowing, who was eventually diagnosed with a huge fibro-vascular polyp after undergoing thoracotomy esophagostomy and excision of the polyp. Case Presentation: A 42-year-old male patient presented to Hallelujah General Hospital, with a 12-year history of difficulty swallowing, associated with symptoms such as weight loss, fatigue, and asphyxiation while vomiting. The patient had visited several health centers but was unable to receive an accurate diagnosis or effective treatment. Initial investigations revealed a large, smooth, and mobile mass in the mid-esophagus, which was obstructing the lumen and causing difficulty swallowing. A CT scan of the chest and abdomen showed a large polypoid mass in the upper and mid-esophagus, measuring 25 cm in length and 10 cm in diameter, which was confirmed to be an esophageal fibro-vascular polyp upon surgical excision and biopsy. Conclusion: EFVPs are rare, benign tumors of the esophagus that can cause significant morbidity if not diagnosed and treated promptly. The diagnosis of EFVPs can be challenging, and imaging studies such as CT scans, MRI, and endoscopic ultrasound can be helpful in diagnosing the condition. However, a definitive diagnosis usually requires histological examination of the excised mass. Surgical excision is the treatment of choice for EFVPs, and the prognosis is usually excellent. This case report highlights the importance of considering rare conditions in the differential diagnosis of common symptoms, particularly if the patient does not respond to initial treatment. It also emphasizes the importance of early diagnosis and prompt surgical intervention in preventing complications and improving outcomes for patients with EFVPs.
{"title":"Choked for Over a Decade: A Rare Case of Huge Esophageal Fibro-vascular Polyp Causing Dysphagia","authors":"S. Kassa, D. Ayalew","doi":"10.59657/2837-2565.brs.23.051","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.23.051","url":null,"abstract":"Introduction: Esophageal fibro-vascular polyps (EFVPs) are rare benign tumors that can arise from the submucosa of the esophagus. They are usually asymptomatic but can cause obstruction and dysphagia in some cases. The diagnosis of EFVPs can be challenging due to their rarity and nonspecific symptoms. Delayed diagnosis can result in significant morbidity, as in the case of our patient who suffered from difficulty swallowing for over a decade before being accurately diagnosed. We present a case of a 42-year-old male patient with a 12-year history of difficulty swallowing, who was eventually diagnosed with a huge fibro-vascular polyp after undergoing thoracotomy esophagostomy and excision of the polyp. Case Presentation: A 42-year-old male patient presented to Hallelujah General Hospital, with a 12-year history of difficulty swallowing, associated with symptoms such as weight loss, fatigue, and asphyxiation while vomiting. The patient had visited several health centers but was unable to receive an accurate diagnosis or effective treatment. Initial investigations revealed a large, smooth, and mobile mass in the mid-esophagus, which was obstructing the lumen and causing difficulty swallowing. A CT scan of the chest and abdomen showed a large polypoid mass in the upper and mid-esophagus, measuring 25 cm in length and 10 cm in diameter, which was confirmed to be an esophageal fibro-vascular polyp upon surgical excision and biopsy. Conclusion: EFVPs are rare, benign tumors of the esophagus that can cause significant morbidity if not diagnosed and treated promptly. The diagnosis of EFVPs can be challenging, and imaging studies such as CT scans, MRI, and endoscopic ultrasound can be helpful in diagnosing the condition. However, a definitive diagnosis usually requires histological examination of the excised mass. Surgical excision is the treatment of choice for EFVPs, and the prognosis is usually excellent. This case report highlights the importance of considering rare conditions in the differential diagnosis of common symptoms, particularly if the patient does not respond to initial treatment. It also emphasizes the importance of early diagnosis and prompt surgical intervention in preventing complications and improving outcomes for patients with EFVPs.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86272683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.59657/2837-2565.brs.23.058
H. Kalkoul, S. Lehachi, M. Chettibi
The Eustachian valve is an embryological remnant of the valve of the inferior vena cava. It may be prominent in some individuals, but the echocardiographic appearance of a divided right atrium (RA) as a result of a large Eustachian valve is rare. Sometimes it presents a problem of differential diagnosis with other embryonic remnants of the right atrium, such as the Chiari network. It may be complicated by thrombosis or infective endocarditis. Cardiac imaging plays an important role in diagnosis. The aim of this review is to discuss a rare form of Eustachian valve complicated by thrombosis.
{"title":"Prominent Eustachian Valve Complicated by Thrombus","authors":"H. Kalkoul, S. Lehachi, M. Chettibi","doi":"10.59657/2837-2565.brs.23.058","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.23.058","url":null,"abstract":"The Eustachian valve is an embryological remnant of the valve of the inferior vena cava. It may be prominent in some individuals, but the echocardiographic appearance of a divided right atrium (RA) as a result of a large Eustachian valve is rare. Sometimes it presents a problem of differential diagnosis with other embryonic remnants of the right atrium, such as the Chiari network. It may be complicated by thrombosis or infective endocarditis. Cardiac imaging plays an important role in diagnosis. The aim of this review is to discuss a rare form of Eustachian valve complicated by thrombosis.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75077797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.59657/2837-2565.brs.23.046
Z. Urakçı, Sezai Tunç, F. Keskin, Hayati Arvas, Z. Oruç, A. Işıkdoğan
The risk of thromboembolism is high in patients with lung adenocarcinoma, especially in patients with ALK rearrangement. The mechanism of thromboembolism due to ALK rearrangement is still unknown. Here, we present a case of diffuse cerebral infarction due to massive thromboembolism in a 25-year-old young male patient with lung adenocarcinoma and ALK rearrangement. Thrombosis, apart from metastasis, should be kept in mind when cranial symptoms develop in patients with lung cancer with ALK rearrangement. In addition, these patients should be followed closely in terms of thrombosis both at diagnosis and during treatment.
{"title":"Diffuse Cerebral Infarction Due to Massive Thromboembolism in A Young Male Patient With ALK-Positive Non-Small Cell Lung Cancer: Is the ALK Rearrangement Related to Thrombosis?","authors":"Z. Urakçı, Sezai Tunç, F. Keskin, Hayati Arvas, Z. Oruç, A. Işıkdoğan","doi":"10.59657/2837-2565.brs.23.046","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.23.046","url":null,"abstract":"The risk of thromboembolism is high in patients with lung adenocarcinoma, especially in patients with ALK rearrangement. The mechanism of thromboembolism due to ALK rearrangement is still unknown. Here, we present a case of diffuse cerebral infarction due to massive thromboembolism in a 25-year-old young male patient with lung adenocarcinoma and ALK rearrangement. Thrombosis, apart from metastasis, should be kept in mind when cranial symptoms develop in patients with lung cancer with ALK rearrangement. In addition, these patients should be followed closely in terms of thrombosis both at diagnosis and during treatment.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88934140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Awareness with recall during general anesthesia is one of the frightening complications of general anesthesia, which indicates the failure of anesthesia. Awareness is an underestimated complication despite the fact that it sometimes carries devastating psychological risks for patients. To our knowledge this is the first research in Syria that reports the incidence of awareness with recall during general anesthesia. Aims: to assess the incidence of awareness with recall during general anesthesia in Damascus University teaching hospitals. Design: Multi-central prospective cohort study. Setting: Three main Teaching Hospitals of Damascus University: Al-Assad, Al-Mowassat & Maternity Hospitals during the time period between January and November 2021. Study Sample: 3500 patients aged ≥ 18 years were included. Results: the incidence of Awareness with recall during general anesthesia in Damascus University Teaching Hospitals was 0.66% in low risk of awareness surgery and 1.8% in high risk of awareness surgeries. The most frequent manifestations of awareness were auditory perceptions, paralysis and pain (100%, 100% & 97.4% respectively). Conclusions: Awareness with recall rate was somehow high in Damascus University Teaching Hospitals in comparison to the figures reported by American and European studies, this difference was especially noted in a low risk of awareness surgery. The rates were similar in the high risk of awareness surgeries. Lack of premedication and low concentration of inhalational agent were the main reasons for awareness.
{"title":"Intraoperative awareness with recall during General Anaesthesia in Damascus University Hospitals in Syria","authors":"Najwa Rekmani, Deemah Soliman, Lamees Mansour, Zakaria Shahoud, Mhd Hosam Barazi","doi":"10.59657/2837-2565.brs.23.029","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.23.029","url":null,"abstract":"Background: Awareness with recall during general anesthesia is one of the frightening complications of general anesthesia, which indicates the failure of anesthesia. Awareness is an underestimated complication despite the fact that it sometimes carries devastating psychological risks for patients. To our knowledge this is the first research in Syria that reports the incidence of awareness with recall during general anesthesia. Aims: to assess the incidence of awareness with recall during general anesthesia in Damascus University teaching hospitals. Design: Multi-central prospective cohort study. Setting: Three main Teaching Hospitals of Damascus University: Al-Assad, Al-Mowassat & Maternity Hospitals during the time period between January and November 2021. Study Sample: 3500 patients aged ≥ 18 years were included. Results: the incidence of Awareness with recall during general anesthesia in Damascus University Teaching Hospitals was 0.66% in low risk of awareness surgery and 1.8% in high risk of awareness surgeries. The most frequent manifestations of awareness were auditory perceptions, paralysis and pain (100%, 100% & 97.4% respectively). Conclusions: Awareness with recall rate was somehow high in Damascus University Teaching Hospitals in comparison to the figures reported by American and European studies, this difference was especially noted in a low risk of awareness surgery. The rates were similar in the high risk of awareness surgeries. Lack of premedication and low concentration of inhalational agent were the main reasons for awareness.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82224643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-12DOI: 10.59657/2837-2565.brs.23.042
Elton Roman
Hematological malignancy is an increasing burden on the Tanzanian healthcare system accounting for around 10% of all cancer diagnosis [1]. Acute myeloid leukemia (AML) is particularly challenging in the context of limited diagnostic services, restricted blood product availability, high cost of chemotherapy drugs and the complete absence of bone marrow transplantation. Despite this Kilimanjaro Christian Medical Centre (KCMC) has attempted to overcome these barriers and has commenced induction therapy with daunorubicin and cytarabine in a number of suitable candidates in an attempt to treat their disease. However, to date treatment during nadir poses an unresolved threat despite the use of prophylactic antiviral, anti-fungal and antibiotic therapies and broad-spectrum antibiotics in the case of infection.
{"title":"A Role for Isoniazid Prophylaxis Against Mycobacterium Tuberculosis During Treatment for Acute Myeloid Leukaemia in Highly Endemic Areas?","authors":"Elton Roman","doi":"10.59657/2837-2565.brs.23.042","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.23.042","url":null,"abstract":"Hematological malignancy is an increasing burden on the Tanzanian healthcare system accounting for around 10% of all cancer diagnosis [1]. Acute myeloid leukemia (AML) is particularly challenging in the context of limited diagnostic services, restricted blood product availability, high cost of chemotherapy drugs and the complete absence of bone marrow transplantation. Despite this Kilimanjaro Christian Medical Centre (KCMC) has attempted to overcome these barriers and has commenced induction therapy with daunorubicin and cytarabine in a number of suitable candidates in an attempt to treat their disease. However, to date treatment during nadir poses an unresolved threat despite the use of prophylactic antiviral, anti-fungal and antibiotic therapies and broad-spectrum antibiotics in the case of infection.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"261 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78999813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-12DOI: 10.59657/2837-2565.brs.23.038
Sandhya P. Powale
Technological developments have taken place in the modern world. Internet Addiction has even been championed as an actual disorder, notably by psychologists Kimberly Young. This paper throws light on facts about Internet addiction and mental health of adolescence have a strong connection. The data collected from secondary sources as books, journals, e-books and various Google sites. There is strong connection between Internet addiction and mental health of adolescence. Due to excess use of internet has harmful detrimental effects on adolescence.
{"title":"Impact of Internet Addiction on Mental Health of Adolescence","authors":"Sandhya P. Powale","doi":"10.59657/2837-2565.brs.23.038","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.23.038","url":null,"abstract":"Technological developments have taken place in the modern world. Internet Addiction has even been championed as an actual disorder, notably by psychologists Kimberly Young. This paper throws light on facts about Internet addiction and mental health of adolescence have a strong connection. The data collected from secondary sources as books, journals, e-books and various Google sites. There is strong connection between Internet addiction and mental health of adolescence. Due to excess use of internet has harmful detrimental effects on adolescence.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90206341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim and Background: Pancytopenia is a reduction of all the three cells of peripheral blood lineage: leukocytes, erythrocytes and platelets. The bone marrow can be primarily hypocellular in pancytopenia either due to reduction of hematopoietic cell production or ineffective haemopoiesis. Generally, infections, toxins or malignant transformation of the marrow are responsible for most of the cases of pancytopenia.1 After the incidence of Covid-19 pandemic, pancytopenia has been seen to occur as a rare complication secondary to SARS-COV 2. Here, we report a unique case of pancytopenia in a previously healthy child with SARS-CoV-2 infection.
{"title":"Pancytopenia as Another Collateral Damage of Covid-19 Infection in a Previously Healthy Child","authors":"Manidipa Barman, Sarthak Chakraborty, Vinodh Kumar","doi":"10.59657/2837-2565.brs.23.044","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.23.044","url":null,"abstract":"Aim and Background: Pancytopenia is a reduction of all the three cells of peripheral blood lineage: leukocytes, erythrocytes and platelets. The bone marrow can be primarily hypocellular in pancytopenia either due to reduction of hematopoietic cell production or ineffective haemopoiesis. Generally, infections, toxins or malignant transformation of the marrow are responsible for most of the cases of pancytopenia.1 After the incidence of Covid-19 pandemic, pancytopenia has been seen to occur as a rare complication secondary to SARS-COV 2. Here, we report a unique case of pancytopenia in a previously healthy child with SARS-CoV-2 infection.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75430671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-12DOI: 10.59657/2837-2565.brs.23.035
S. M. M Sabra
Microbial biofilms exist in wounds resulting in long-term non-healing infected wounds. Herbal products as ancient traditions treatment and scientists in developing countries using in wounds healing over years. Arabic Acacia present in KSA, it's using in production of some medications. It has gallic-acid, methyl-gallate, quercetin, rutin, myricetin 3-O-(3'''-O -galloyl), β-D-rutinoside and catechin. It has a significant antimicrobial agent. Its extract provided fast wounds healing related to antimicrobial activities. The aim was to prove "Traditional Treatment" by Arabic Acacia Seeds exterminate microbial biofilms for wounds healing. Materials and methods were included Arabic Acacia aqueous extract, biofilm isolates included (Staphylococcus sp., Streptococcus sp., Pseudomonas sp., Proteus sp., Escherichia coli, also Klebsiella sp., and Candida sp.)) The applied tests were anti-biofilms formation and biofilms elimination, then biofilm estimation by Tissue Culture Plate method (TCP). Results were for estimation of anti-biofilms formation after exposed to Arabic Acacia aqueous extract. It was eliminated by simple Arabic Acacia aqueous extract early by crude dilution in overnight time were Streptococcus sp., and Proteus sp. Then by crude dilution in day time were Escherichia coli, also Klebsiella sp. Staphylococcus sp., Pseudomonas sp., and Candida sp., they had reached the weak point only. Estimation of biofilms elimination after exposed to Arabic Acacia aqueous extract. The effects of all dilutions were faster than anti-biofilms formation. This was giving none for Streptococcus sp., and Proteus sp., by half dilution for overnight. While Streptococcus sp., Proteus sp., Escherichia coli also Klebsiella sp. were resulted none by half dilution for a day. Crude dilution gave none for all biofilms elimination in both times. It was concluded that the Arabic Acacia aqueous extract had microbial anti-biofilms formation. That was by their antimicrobial contents exterminating microbial biofilms for wounds healing. This indicated the using from ancient Arab customs to treat wounds as traditional treatment. It was recommended that for the "Traditional Treatment" of Arabic Acacia extract according healthy doses as simple treatment instead of chemical treatment for wounds healing.
创面内存在微生物生物膜，导致创面感染长期不愈合。草药产品作为古老的传统疗法和发展中国家的科学家多年来在伤口愈合中使用。阿拉伯金合欢存在于沙特阿拉伯，它被用于生产一些药物。它含有没食子酸、没食子酸甲酯、槲皮素、芦丁、杨梅素3- o -(3'' - o -没食子酰)、β- d -芦丁苷和儿茶素。它有一个重要的抗菌剂。其提取物具有快速愈合伤口的抗菌活性。其目的是证明阿拉伯刺槐种子的“传统疗法”可以消灭微生物生物膜，促进伤口愈合。材料和方法包括阿拉伯相思水提液，生物膜分离物包括(葡萄球菌、链球菌、假单胞菌、变形杆菌、大肠杆菌、克雷伯氏菌和念珠菌)。应用试验是抗生物膜的形成和消除，然后用组织培养板法(TCP)估计生物膜。结果用于估计阿拉伯金合欢水提物暴露后抗生物膜的形成。单纯阿拉伯刺槐水提物经隔夜粗稀释早期除菌主要为链球菌和变形杆菌，白天粗稀释后除菌主要为大肠杆菌、克雷伯氏菌、葡萄球菌、假单胞菌和念珠菌，仅达弱点。阿拉伯刺槐水提物暴露后生物膜消除的估计。所有稀释的效果都快于抗生物膜的形成。这是对链球菌和变形杆菌进行一半稀释过夜的结果。而链球菌、变形杆菌、大肠杆菌和克雷伯氏杆菌在稀释一半的情况下一天均未产生。在两次试验中，粗稀释均不能消除所有生物膜。结论:阿拉伯刺槐水提物具有微生物抗生物膜的形成。这是因为它们的抗菌成分消灭了伤口愈合的微生物生物膜。这表明从古代阿拉伯习俗中使用传统的治疗方法来治疗伤口。建议在"传统治疗"中，按健康剂量使用阿拉伯金合欢提取物作为简单治疗，而不是化学治疗，以促进伤口愈合。
{"title":"Traditional Treatment by Arabic Acacia Seeds Exterminating Microbial Biofilms for Wounds Healing","authors":"S. M. M Sabra","doi":"10.59657/2837-2565.brs.23.035","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.23.035","url":null,"abstract":"Microbial biofilms exist in wounds resulting in long-term non-healing infected wounds. Herbal products as ancient traditions treatment and scientists in developing countries using in wounds healing over years. Arabic Acacia present in KSA, it's using in production of some medications. It has gallic-acid, methyl-gallate, quercetin, rutin, myricetin 3-O-(3'''-O -galloyl), β-D-rutinoside and catechin. It has a significant antimicrobial agent. Its extract provided fast wounds healing related to antimicrobial activities. The aim was to prove \"Traditional Treatment\" by Arabic Acacia Seeds exterminate microbial biofilms for wounds healing. Materials and methods were included Arabic Acacia aqueous extract, biofilm isolates included (Staphylococcus sp., Streptococcus sp., Pseudomonas sp., Proteus sp., Escherichia coli, also Klebsiella sp., and Candida sp.)) The applied tests were anti-biofilms formation and biofilms elimination, then biofilm estimation by Tissue Culture Plate method (TCP). Results were for estimation of anti-biofilms formation after exposed to Arabic Acacia aqueous extract. It was eliminated by simple Arabic Acacia aqueous extract early by crude dilution in overnight time were Streptococcus sp., and Proteus sp. Then by crude dilution in day time were Escherichia coli, also Klebsiella sp. Staphylococcus sp., Pseudomonas sp., and Candida sp., they had reached the weak point only. Estimation of biofilms elimination after exposed to Arabic Acacia aqueous extract. The effects of all dilutions were faster than anti-biofilms formation. This was giving none for Streptococcus sp., and Proteus sp., by half dilution for overnight. While Streptococcus sp., Proteus sp., Escherichia coli also Klebsiella sp. were resulted none by half dilution for a day. Crude dilution gave none for all biofilms elimination in both times. It was concluded that the Arabic Acacia aqueous extract had microbial anti-biofilms formation. That was by their antimicrobial contents exterminating microbial biofilms for wounds healing. This indicated the using from ancient Arab customs to treat wounds as traditional treatment. It was recommended that for the \"Traditional Treatment\" of Arabic Acacia extract according healthy doses as simple treatment instead of chemical treatment for wounds healing.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"154 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90680478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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