Perbedaan Kadar Protein Human Cpp (Copeptin) Berdasarkan Lama Menderita Pada Pasien Diabetes Melitus

Diabetes mellitus is a big public health problem in Indonesia. The length of time of suffering from DM is associated with a decrease in the function of pancreatic beta cells resulting in insulin resistance, which occurs in type 2 diabetes mellitus. Insulin resistance can be determined by measuring copeptin levels. The aim of this study was to determine differences in levels of human CPP protein (copeptin) in diabetes mellitus patients based on length of suffering. This type of research is observational analytic with cross sectional research design. Samples were taken from diabetes mellitus outpatients at Roemani Muhammadiyah Hospital as many as 20 samples, then the samples were examined for levels of human CPP (copeptin) protein using the ELISA (Enzyme Linked Immunosorbent Assay) method. The results showed that the average copeptin level in patients with diabetes mellitus ≤ 3 years was 1054 pg/mL and the average copeptin level in patients with diabetes mellitus > 3 years was 899 pg/mL. Statistical tests using the Independent Sample T Test obtained a significant sig value of 0.027 with a significance level of 0.05, namely 0.027 <0.05 so that it can be concluded that there are differences in copeptin levels in diabetes mellitus patients based on length of suffering. Copeptin levels in patients with diabetes mellitus ≤ 3 years, namely 1054 pg/mL, were higher than copeptin levels in patients with diabetes mellitus > 3 years, namely 899 pg/mL