Wing Ho Chau , Chung Yan Cheung , Hung Wing Li , Man Shing Wong
{"title":"用于阿尔茨海默病早期诊断的无创检测试剂盒","authors":"Wing Ho Chau , Chung Yan Cheung , Hung Wing Li , Man Shing Wong","doi":"10.1016/j.inv.2022.100004","DOIUrl":null,"url":null,"abstract":"<div><p>The present invention discloses a new Alzheimer's disease (AD) diagnostic kit that tests blood, saliva and urine, providing a faster, more sensitive, affordable and non-invasive way than conventional method of detection. This detection assay only requires a few microliters of the body fluids to quantify the target AD-related protein biomarkers.</p><p>The assay is based on the immunoreaction between the target protein biomarkers and their corresponding pair of antibodies followed by fluorescence labelling with a newly developed cyanine turn-on fluorophore. The intensity of the fluorescence signal can act as an index to evaluate the severity of AD.</p><p>Therefore, the present invention can serve as an analytical tool for early diagnosis, progression monitoring and staging.</p></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"2 ","pages":"Article 100004"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772444122000027/pdfft?md5=82b6043b5d2b8be28ed524385c2f30d5&pid=1-s2.0-S2772444122000027-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Non-invasive detection kit for early diagnosis of Alzheimer's disease\",\"authors\":\"Wing Ho Chau , Chung Yan Cheung , Hung Wing Li , Man Shing Wong\",\"doi\":\"10.1016/j.inv.2022.100004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The present invention discloses a new Alzheimer's disease (AD) diagnostic kit that tests blood, saliva and urine, providing a faster, more sensitive, affordable and non-invasive way than conventional method of detection. This detection assay only requires a few microliters of the body fluids to quantify the target AD-related protein biomarkers.</p><p>The assay is based on the immunoreaction between the target protein biomarkers and their corresponding pair of antibodies followed by fluorescence labelling with a newly developed cyanine turn-on fluorophore. The intensity of the fluorescence signal can act as an index to evaluate the severity of AD.</p><p>Therefore, the present invention can serve as an analytical tool for early diagnosis, progression monitoring and staging.</p></div>\",\"PeriodicalId\":100728,\"journal\":{\"name\":\"Invention Disclosure\",\"volume\":\"2 \",\"pages\":\"Article 100004\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2772444122000027/pdfft?md5=82b6043b5d2b8be28ed524385c2f30d5&pid=1-s2.0-S2772444122000027-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Invention Disclosure\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772444122000027\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Invention Disclosure","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772444122000027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Non-invasive detection kit for early diagnosis of Alzheimer's disease
The present invention discloses a new Alzheimer's disease (AD) diagnostic kit that tests blood, saliva and urine, providing a faster, more sensitive, affordable and non-invasive way than conventional method of detection. This detection assay only requires a few microliters of the body fluids to quantify the target AD-related protein biomarkers.
The assay is based on the immunoreaction between the target protein biomarkers and their corresponding pair of antibodies followed by fluorescence labelling with a newly developed cyanine turn-on fluorophore. The intensity of the fluorescence signal can act as an index to evaluate the severity of AD.
Therefore, the present invention can serve as an analytical tool for early diagnosis, progression monitoring and staging.
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