Invention Disclosure最新文献

In this invention, a novel cancer drug is formed by Cu(II) and Fe(III) binding the medicinal molecule Paclitaxel (PAC). This complexation increases the water solubility of the taxane, alters the structure so resistance mechanisms do not recognize it, and adds additional toxicity. The copper (II) species can generate reactive oxidation species (ROS) and randomly bind and distort proteins within a cancer cell. Cu(II) also plays a role in accelerating angiogenesis and creates a Trojan horse effect that increases its uptake rate by the cancer cells. The empirical formula for the complex is Cu_xFe_yPAC₁, where X + Y equals a value between 0 and 10.

A one-pot hydrothermal carbonization-sulfonation procedure was employed to develop robust, carbon-based solid catalyst sulfonic acid functionalized carbonaceous material (SAFACAM) possessing acidic functions up to 5.31 mmol g⁻¹ for the first time at 80 °C. With its atom-efficient, one-pot preparation from a plentiful natural biomass derivative (glucose), the current catalyst benefits the environment and has the potential to lower the overall cost of producing biodiesel by converting cheap raw materials. The diminishing supply of fossil fuels coupled with the polluting effects of their use is driving the quest for more sustainable sources of energy. The pursuit of producing biodiesel from affordable, non-edible oil has become progressively significant due to its dual benefits of sustainability and cost-efficiency. In this context, Jatropha curcas oil (JCO) has gained attention in the energy sector, as it holds promise as a viable feedstock for biodiesel manufacturing and a renewable energy solution for numerous nations. Additionally, the catalyst exhibited exceptional physical stability and reactivity throughout 5 consecutive cycles, establishing its potential as a highly promising catalyst for sustainable biodiesel manufacture.

With the ever-increasing adoption of solar energy and the lack of space for PV installations, targeting maximum photovoltaic operational efficiencies has become essential. One of the key challenges faced by PV installations in warm climates is thermal management, which is caused by increasing temperatures due to PV conversion inefficiencies and limited ventilation possibilities in certain installations. Despite prior art, further improvement is still needed to provide a novel system that can offer more efficient and controllable temperature decrease of photovoltaic modules in both land and offshore installations. The present invention, termed IPCoSy, satisfies the aforementioned needs in the art by providing a novel system for cooling a solar panel assembly, including at least one photovoltaic module having a plurality of solar cells generating electrical power and a PV junction box attached to the back of the photovoltaic module. A part of this invention discloses a new type of PV module that is a modification of standard commercial modules. This new PV module incorporates a water chamber at the back of a solar cell assembly to regulate operational temperatures. Another part of this invention presents an after-market cooling system that can be fitted to existing standard PV modules to add the cooling effect. This part of the invention presents solid and flexible water tanks that can be fitted directly into a gap at the back of standard PV modules. Moreover, this invention presents details on parts that distinguish this cooling system from prior art, such as an internal stream spreader to obtain better fluid dynamics and external fittings that allow the PV module to be installed at any tilt angle without jeopardizing the cooling effect. Finally, this invention discloses different application areas of this cooling system, such as residential and industrial water heating, reverse osmosis plants and offshore photovoltaic installations, showcasing the product's versatility, adaptability and large market suitability.

Plastic waste is one of the world's biggest sources of pollution. Despite the growing trend towards recycling, there are currently no effective technologies to offset the continuous increase in plastic production. Polyesters and polyamides are among the most widely produced single-use plastics, mainly used in the manufacture of textiles and soft drink bottles. Currently, only a small proportion of these polymers can be effectively recycled. The two primary methods employed for this purpose are mechanical and chemical recycling. Presently, mechanical recycling remains the more widely adopted process within the industrial sector. However, the treatment process is limited to a narrow range of waste materials as it is impossible to remove dyes and the mechanical properties deteriorate due to incompatibility between different plastic materials. Another critical limit of this recycling technology is the limited number of recycling loops that can be done due to the thermal degradation that occurs during the extrusion process. The alternative option is chemical recycling, which allows the depolymerization of the original product to recover the monomers directly. The main drawbacks are the long reaction times and the many solvents needed to achieve high-purity products. As a results, chemical recycling is only economically feasible for large companies that can produce the virgin polymer in situ. In this work, a new technology has been patented. This process consists of three main steps. The first one is the distillation-assisted cyclodepolymerization (DA-CDP), introduced as a modification of the CDP process. In this unit, cyclic oligomers together with high molecular weight compounds are produced. Then, after polymer purification, it is possible to achieve the same molecular weight as the initial polymer in less than 30 min, exploiting the ring-opening polymerization (ROP) of the next step.

The transesterification of soybean oil (SO) to biodiesel utilizing a basic CaO nanocatalyst derived from waste snail shells has been reported in this work. The steady rise in greenhouse gas emissions contributes to environmental pollution, posing a significant threat to human life due to the escalating rates of petroleum consumption worldwide. Thus, biodiesel appears as a potential liquid fuel for replacing petroleum diesel. Here we have utilized waste snail shells as a cost-effective material which will reduce the overall biodiesel manufacturing cost. We obtained a remarkable biodiesel yield of 96.1 % with a very low activation energy (30.45 kJ mol⁻¹). The catalyst displayed exceptional stability, maintaining consistent catalytic activity over six consecutive cycles without experiencing a notable decline. Using life cycle cost analysis (LCCA) it has been discovered that the estimated cost of producing 1 kg of biodiesel is merely $ 0.935, highlighting its robust potential for extensive commercial adoption.

Dysphagia, a serious health issue, is common in healthcare residents and the elderly. The invention provides a method and a formulation for preparing and using a special medical food product for people with dysphagia. The main raw materials used include starch, corn oil, and soy protein. The preparation method of the product is simple, and the concentration can be adjusted to meet the needs of different patients with dysphagia, so that the patients with dysphagia can consume the product safely, and the risk of accidental aspiration can be effectively reduced. The whole nutrition special medical use formula food of the present invention can provide sufficient nutrients, and can meet the basic nutritional requirements needed by the population of patients with dysphagia.

The electrical activity plays a vital role in the physiological functions of live organisms, electrical stimulation has been identified as a promising nonpharmacological technique that can modulate the behavior of cellular network, restore and monitoring critical functions and accelerate tissue healing in vitro and in vivo. The red blood cell (RBC) membrane contains proteins and glycoproteins embedded in a fluid lipid bilayer that confers viscoelastic behavior. Sialylated glycoproteins of the RBC membrane are responsible for a negatively charged surface which creates a repulsive electric zeta potential (ζ)between cells. These charges help prevent the interaction between RBCs and the other cells and especially between each other. The zeta potential is a physical property which is exhibited by all particles in suspension. In this context we present for the first time the invention concerns the field of measurement of physiological parameters for determining cardiac output (CO), plus specifically refers to a new apparatus for determination of cardiac output based on determination of the electrical charges induced on the membrane of the RBC (electrical polarization of red blood cells).