溴化乙啶-赫斯特33258-DNA和溴化乙啶-亚甲基蓝- dna三元体系的紫外熔融行为

P. O. Vardevanyan, A. Antonyan, M. Parsadanyan, M. Shahinyan, Gayane A. Melkonyan
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引用次数: 9

摘要

研究了EtBr与H33258的相互作用以及EtBr与MB与DNA的相互作用。结果表明,在联合作用下,两种配体对EtBr-DNA-H33258或EtBr-DNA-MB配合物熔融热力学参数变化的影响不是单独相互作用影响的增加。结果表明,在结合时,EtBr和MB与DNA竞争发生结合,而在EtBr和H33258的情况下,主要是它们各自对DNA双链结构的稳定作用相互加强。
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Behavior of Ethidium Bromide-Hoechst 33258-DNA and Ethidium Bromide-Methylene Blue-DNA Triple Systems by means of UV Melting
The study of EtBr and H33258 interaction as well as EtBr and MB interaction with DNA has been carried out. It was revealed that, at joint interaction, the effect of two ligands on the change of melting thermodynamic parameters of EtBr-DNA-H33258 or EtBr-DNA-MB complexes is not an addition of separate interaction influences. It was shown that, at joint, binding of EtBr and MB with DNA competition occurs, while in the case of EtBr and H33258, the mutual strengthening of stabilizing effect of each of them on DNA double-stranded structure mainly takes place.
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