印度恰蒂斯加尔邦某三级医院药物警戒项目实验室信号检测肺炎球菌感染病毒患者莫西沙星严重不良反应发生率

Vandna Dewangan, Ram Kumar Sahu, T. Satapathy
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摘要

患者直接报告药物不良反应正日益成为药物警戒医院讨论的重要话题。药品不良反应(ADR)自愿报告是医疗药品安全监测的基础;然而,存在大量的报告不足,这是该制度的主要限制。此时,医院接受消费者报告。世界卫生组织估计,2005年以及2019-2021年,肺炎球菌感染导致全球160万人死亡。肺炎,肺部充满液体并发炎,导致呼吸困难。对一些人来说,呼吸问题可能严重到需要在医院接受吸氧甚至呼吸机治疗。COVID-19引起的肺炎往往会在两个肺中扎根。莫西沙星是一种氟喹诺酮类抗生素,用于治疗呼吸道、盆腔炎、皮肤和腹腔内感染。其安全性在大多数评论中被认为是有利的,但在罕见但潜在致命的毒性方面受到挑战。最常见的药物不良反应(ADR)便秘是恶心、呕吐、疲劳、脱发、嗜睡、骨髓抑制、皮肤反应、厌食症、粘膜炎、腹泻。与药物不良反应相关的住院治疗特别涉及的药物包括抗血小板、抗凝血剂、细胞毒素、免疫抑制剂、利尿剂、抗糖尿病药和抗生素。
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Incidence of Moxifloxacin serious adverse drug reactions in Pneumococcal infections virus infected patients detected by a Pharmacovigilance program by laboratory signals in a Tertiary hospital in Chhattisgarh (India)
The direct reporting of adverse drug reactions by patients is becoming an increasingly important topic for discussion in the hospital of Pharmacovigilance. Voluntary adverse drug reaction (ADR) reporting is fundamental to medical drug safety surveillance; however, substantial under-reporting exists and is the main limitation of the system. At this time, hospital accepts consumer reports. The World Health Organization estimates that in 2005 and as well as 2019-2021 pneumococcal infections were responsible for the death of 1.6 million human worldwide. Pneumonia, the lungs become filled with fluid and inflamed, leading to breathing difficulties. For some people, breathing problems can become severe enough to require treatment at the hospital with oxygen or even a ventilator. The pneumonia that COVID-19 causes tends to take hold in both lungs. Moxifloxacin, a fluoroquinolone antibiotic, is used for the treatment of respiratory tract, pelvic inflammatory disease, skin, and intra-abdominal infections. Its safety profile is considered favorable in most reviews but has been challenged with respect to rare but potentially fatal toxicities. The most common adverse drug reaction (ADR) constipation is nausea, vomiting, fatigue, alopecia, drowsiness, myelosuppression, skin reactions, anorexia, mucositis, diarrhoea and Medicines that have been particularly implicated in adverse drug reaction-related hospital admissions include anti-platelets, anticoagulants, cytotoxics, immunosuppressant’s, diuretics, anti-diabetics and antibiotics.
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