住院个体中covid阳性患者慢性肾脏疾病(CKD)检测的生化指标评价

T. Pathak, S. Bera, Devnil Pathak, P. Maity, Rajdeep Paul, Monika Ghosh
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摘要

在covid-19阳性患者中,可通过红细胞生成素水平、胱抑素-c (CysC)、BTP (β微量蛋白)、IL- 6、IL-8、TNF α等少数生化指标检测CKD的诊断价值。这些化学参数通常可能是潜在的诊断方面。该研究旨在确定每周接受两次透析的covid阳性患者CKD生化标志物的患病率,并评估salboni超级专科医院WB的50名ICU和非ICU患者的危险因素,为期6个月(2020年6月至2020年11月)。采用静脉穿刺法采集ICU患者和非ICU患者的血样,并从全血中分离血清。然后对血清样本进行CLIA免疫分析法检测这些生物标志物。红细胞生成素水平在40-49岁年龄组和50-59岁年龄组中显著降低,而在30-39岁年龄组中,男性EPO水平显著降低。而其余年龄组的EPO水平则显著升高。其余年龄组(40 ~ 49岁)男性各组β微量蛋白含量均显著升高。各组血清胱抑素C、IL-6、IL-8、TNF α水平均显著升高。这与covid患者CKD的生化标志物形成鲜明对比,其中许多标志物对临床医生来说是新的和不熟悉的,相对昂贵,并且与目前的方法相比缺乏已证明的临床益处,无法充分证明其广泛实施的理由。
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Evaluation of biochemical markers for detection of chronic kidney diseases (CKD) in covid positive patient among hospitalize individuals
In evaluating diagnosis of CKD can detect in covid-19 positive patient by estimation of few bio-chemical markers like erythropoietin level, cystatin-C (CysC), BTP (beta trace protein.), IL- 6, IL-8 and TNF alpha. Those chemical parameters usually may be potential diagnostic aspect. The study was undertaken to determine the prevalence of biochemical markers of CKD in covid positive patients those are taking dialysis twice in a week and also to evaluate the risk factors among 50 ICU and non-ICU individuals at salboni super speciality hospital, WB over a period of 6 months (June 2020 to Nov 2020). Blood samples were collected by using venipuncture technique from ICU and non-ICU individuals then serum is separated from the whole blood sample. Then the serum samples were performing CLIA immunoassay technique for detecting those biomarkers. Erythropoietin level was decreased significantly across CKD in age group (40-49) and also age group (50-59) for female and for the male age group (30-39) is significantly decreased in EPO level. Whereas the rest age groups are significantly increased in EPO level. Beta trace protein of all the groups are significantly increased remaining age group (40-49) for male. Cystatin C level, IL-6, IL-8, TNF alpha level is significantly increased of all the groups both male and female. This is in contrast to the bio-chemical markers of CKD in covid patient, many of which are new and unfamiliar to clinicians, relatively costly, and lack the demonstrated clinical benefit over current methods to fully justify their wide implementation.
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