{"title":"复方制剂对链脲佐菌素诱导的糖尿病大鼠模型的抗糖尿病活性评价","authors":"Dr. P. Solairaj, .. Jebaseelan","doi":"10.26510/2394-0859.PBE.2017.17","DOIUrl":null,"url":null,"abstract":"Objective: The present work was executed to evaluate the anti-diabetic potency of a polyherbal preparation. The objective of this study is to induce experimental diabetes mellitus using streptozotocin in normal Albino wistar rats and study the antdiabetic activity of polyherbal formulation by comparison of changes in levels of glucose between normal and diabetic rats . Methods: The effect of methanol extract of poly herbal preparation containing aerial parts of Schrebera swietenoides, roots of Barleria montana and aerial parts of Rotula aquatica was investigated in normal and streptozotocin induced diabetic rats. Results: The lowest blood glucose levels were observed at 4 and 8 th hr after the oral administration of 150 and 300 mg/kg b.w polyherbal formulation. The blood glucose levels at 24hrs after the oral administration of 150 and 300 mg/kg b. w of poly herbal formulation was significantly lowers the blood glucose levels. Conclusions: The display of synergy or antagonism by the composite herbal extracts in ameliorating hyperglycemia depended on the type and number of individual herbal extract used in constituting the experimental herbal formulations.","PeriodicalId":19998,"journal":{"name":"Pharmaceutical and Biological Evaluations","volume":"1 1","pages":"111-117"},"PeriodicalIF":0.0000,"publicationDate":"2017-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Preparation and evaluation of polyherbal formulation for its antidiabetic activity against streptozotocin induced diabetes rat model\",\"authors\":\"Dr. P. Solairaj, .. Jebaseelan\",\"doi\":\"10.26510/2394-0859.PBE.2017.17\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: The present work was executed to evaluate the anti-diabetic potency of a polyherbal preparation. The objective of this study is to induce experimental diabetes mellitus using streptozotocin in normal Albino wistar rats and study the antdiabetic activity of polyherbal formulation by comparison of changes in levels of glucose between normal and diabetic rats . Methods: The effect of methanol extract of poly herbal preparation containing aerial parts of Schrebera swietenoides, roots of Barleria montana and aerial parts of Rotula aquatica was investigated in normal and streptozotocin induced diabetic rats. Results: The lowest blood glucose levels were observed at 4 and 8 th hr after the oral administration of 150 and 300 mg/kg b.w polyherbal formulation. The blood glucose levels at 24hrs after the oral administration of 150 and 300 mg/kg b. w of poly herbal formulation was significantly lowers the blood glucose levels. Conclusions: The display of synergy or antagonism by the composite herbal extracts in ameliorating hyperglycemia depended on the type and number of individual herbal extract used in constituting the experimental herbal formulations.\",\"PeriodicalId\":19998,\"journal\":{\"name\":\"Pharmaceutical and Biological Evaluations\",\"volume\":\"1 1\",\"pages\":\"111-117\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutical and Biological Evaluations\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26510/2394-0859.PBE.2017.17\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutical and Biological Evaluations","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26510/2394-0859.PBE.2017.17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
目的:评价一种复方中药制剂的抗糖尿病作用。本研究采用链脲佐菌素诱导正常白化wistar大鼠实验性糖尿病,并通过比较正常大鼠和糖尿病大鼠葡萄糖水平的变化,研究复方的抗糖尿病活性。方法:采用链脲佐菌素诱导的糖尿病大鼠和正常大鼠实验,考察含甜菊属、大黄菜根和水轮藤属空中部位的复方中药制剂甲醇提取物对糖尿病大鼠的影响。结果:口服复方150、300 mg/kg b.w后4、8小时血糖最低。口服复方150、300 mg/kg b. w后24h血糖水平显著降低。结论:复方中草药提取物对高血糖的增效或拮抗作用取决于组成实验中草药配方的单个中草药提取物的种类和数量。
Preparation and evaluation of polyherbal formulation for its antidiabetic activity against streptozotocin induced diabetes rat model
Objective: The present work was executed to evaluate the anti-diabetic potency of a polyherbal preparation. The objective of this study is to induce experimental diabetes mellitus using streptozotocin in normal Albino wistar rats and study the antdiabetic activity of polyherbal formulation by comparison of changes in levels of glucose between normal and diabetic rats . Methods: The effect of methanol extract of poly herbal preparation containing aerial parts of Schrebera swietenoides, roots of Barleria montana and aerial parts of Rotula aquatica was investigated in normal and streptozotocin induced diabetic rats. Results: The lowest blood glucose levels were observed at 4 and 8 th hr after the oral administration of 150 and 300 mg/kg b.w polyherbal formulation. The blood glucose levels at 24hrs after the oral administration of 150 and 300 mg/kg b. w of poly herbal formulation was significantly lowers the blood glucose levels. Conclusions: The display of synergy or antagonism by the composite herbal extracts in ameliorating hyperglycemia depended on the type and number of individual herbal extract used in constituting the experimental herbal formulations.