角质层屏障——从分子尺度到宏观性质

IF 7.9 2区化学 Q1 CHEMISTRY, PHYSICAL Current Opinion in Colloid & Interface Science Pub Date : 2023-10-01 DOI:10.1016/j.cocis.2023.101725

Emma Sparr , Sebastian Björklund , Q. Dat Pham , Enamul H. Mojumdar , B. Stenqvist , M. Gunnarsson , D. Topgaard

{"title":"角质层屏障——从分子尺度到宏观性质","authors":"Emma Sparr , Sebastian Björklund , Q. Dat Pham , Enamul H. Mojumdar , B. Stenqvist , M. Gunnarsson , D. Topgaard","doi":"10.1016/j.cocis.2023.101725","DOIUrl":null,"url":null,"abstract":"<div><p>The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.</p></div>","PeriodicalId":293,"journal":{"name":"Current Opinion in Colloid & Interface Science","volume":"67 ","pages":"Article 101725"},"PeriodicalIF":7.9000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S135902942300050X/pdfft?md5=6b5e498891bb4188697d716c88eedff3&pid=1-s2.0-S135902942300050X-main.pdf","citationCount":"1","resultStr":"{\"title\":\"The stratum corneum barrier – From molecular scale to macroscopic properties\",\"authors\":\"Emma Sparr , Sebastian Björklund , Q. Dat Pham , Enamul H. Mojumdar , B. Stenqvist , M. Gunnarsson , D. Topgaard\",\"doi\":\"10.1016/j.cocis.2023.101725\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.</p></div>\",\"PeriodicalId\":293,\"journal\":{\"name\":\"Current Opinion in Colloid & Interface Science\",\"volume\":\"67 \",\"pages\":\"Article 101725\"},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S135902942300050X/pdfft?md5=6b5e498891bb4188697d716c88eedff3&pid=1-s2.0-S135902942300050X-main.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Colloid & Interface Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S135902942300050X\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Colloid & Interface Science","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S135902942300050X","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 1

摘要

我们皮肤的上层，角质层(SC)，是一种多功能材料，结合了机械强度和有效的屏障功能。在本文中，我们讨论了这些宏观性质的SC的分子反应和结构多样性的SC蛋白和脂质的最新发现。我们特别关注中间(胶体)长度尺度，以及不同的SC亚结构如何相互组织，包括皮肤中非平衡条件对水和其他成分梯度的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

The stratum corneum barrier – From molecular scale to macroscopic properties

The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current Opinion in Colloid & Interface Science 化学-物理化学

CiteScore

16.50

自引率

1.10%

发文量

审稿时长

11.3 weeks

期刊介绍： Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.

期刊最新文献

Dye-sensitized solar cells (DSSC): Principles, materials and working mechanism Fundamentals in organic dyes for perovskite solar cells A critical examination of the physics behind the formation of particle-laden fluid interfaces Protorheology in practice: Avoiding misinterpretation Rheological effects of rough colloids at fluid interfaces: An overview