N-(2-羟乙基)哌嗪-N'-4-丁磺酸(HEPBS)生理pH缓冲液标准(5 ~ 55℃

L. N. Roy, R. Roy, K. A. Allen, Casey J. Mehrhoff, Isaac B. Henson, Jessica M. Stegner, Zachary M. Downs
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引用次数: 1

摘要

采用贝茨-古根海姆惯例和扩展的德拜-哈克方程,在5 ~ 55℃的12个温度下,计算了6种摩尔标度相等的缓冲溶液和8种离子强度(I = 0.16 mol·kg -1)与血浆浓度相似的缓冲溶液的pH值。通过流动结池测量得到了HEPBS缓冲溶液的Ej值。这些Ej值被用来确定HEPBS缓冲溶液在25和37°C下的工作pH值。生理磷酸盐缓冲液在25℃和37℃时的pH值分别为7.415和7.395。两性离子缓冲液HEPBS被证明是有用的,在接近血清的区域作为二级pH标准。
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Buffer Standards for the Physiological pH of N-(2-Hydroxyethyl) piperazine-N'-4-butanesulfonic Acid (HEPBS) from 5 to 55 °C
The pH values of six buffer solutions of equal compositions on the molal scale and eight buffer solutions hav- ing ionic strengths (I = 0.16 mol·kg -1 ) similar to the concentration of blood plasma have been evaluated at 12 temperatures from 5 to 55 °C using the Bates-Guggenheim convention and extended Debye-Huckel equation. The values of Ej for the buffer solution of HEPBS have been obtained from the flowing junction cell measurement. These values of Ej have been used to ascertain the operational pH values at 25 and 37 °C for HEPBS buffer solution. The pH values at 25 and 37 °C are 7.415 and 7.395, respectively, for physiological phosphate buffer solutions. The zwitterionic buffer HEPBS was shown to be useful as a secondary pH standard in the region close to that of blood serum.
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