Making Sense of the Expanding Class of Biologics: A Focus on Nail Psoriasis

This article reviews the different clinical presentations of nail psoriasis depending on which nail structure is involved, discusses which first-line treatments are most efficacious depending on the nail structure involved, and highlights the biologic therapies that stand out as superior in newer nail psoriasis studies. The expanding class of biologics and their associated nuances can be overwhelming when determining which is the best fit for a specific psoriasis patient; thus, this manuscript as well aims to reduce confusion related to biologics by presenting a brief history of biologics, providing a review of the current biologics approved for psoriasis and psoriatic arthritis in the United States, along with a concise set of tables to help simplify decision-making with biologics.