新型血管内支架治疗复杂腹主动脉瘤的血流动力学机制研究

Baotong Li, Yuechao Zhao, Hansong Sun, Shanglin Chen
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摘要

目的应用计算流体动力学(CFD)分析新型血管内支架治疗复杂腹主动脉瘤的血流动力学机制,并比较新型血管内支架与流线型多层血流调节剂(streamliner multilayer flow modulator, SMFM)支架的效果。方法所有医学图像均采用计算机断层扫描。Mimics(v17.0;Materialise, Leuven, Belgium)用于提取三维主动脉瘤。该支架是数字生成的,并沿主动脉瘤安装。流明体积代表了离散成更小体积的流体域,这在ICEM软件(Ansys ICEM CFD v15.0)中定义了一个网格。采用Fluent 16.0软件进行血流动力学分析。结果两种支架均能改变血流分布模式。与SMFM相比,新型血管内支架可以显著降低动脉瘤内的流速、剪切力和对动脉瘤壁的压力。此外,新型血管内支架可加快分支动脉的流速。结论新型血管内支架能显著降低动脉瘤内血流速度,减小动脉瘤壁上的剪切力和压力,加快分支动脉血流速度。关键词:主动脉瘤;计算流体力学;流线型多层流量调制器;新型血管内支架
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The study of hemodynamic mechanism of a novel endovascular stent on complicated abdominal aortic aneurysms
Objective To detect the hemodynamic mechanism of the novel endovascular stent on complicated abdominal aortic aneurysms by Computational Fluid Dynamics(CFD) firstly, and then compare the effect of the novel endovascular stent and the streamliner multilayer flow modulator(SMFM) stent. Methods All medical images were obtained by computed tomography. A semiautomatic segmentation protocol within Mimics(v17.0; Materialise, Leuven, Belgium) was used to extract the threedimensional aortic aneurysms. The stents was generated numerically and fitted along the aortic aneurysms. The lumen volume represented the fluid domain that was discretised in smaller volumes, which defined a mesh within the ICEM software(Ansys ICEM CFD v15.0). Hemodynamic analysis was performed with software Fluent 16.0. Results Both kinds of stents can change the pattern of flow distribution. Compared with SMFM, the novel endovascular stent can significantly reduce the flow velocity in aneurysms, the shear force and the pressure on the aneurysms wall.What’s more, the flow velocity of the branch artery was accelerated by the novel endovascular stent. Conclusion The novel endovascular stent can significantly reduce the flow velocity in aneurysms, the shear force and the pressure on the aneurysms wall, and acceleratethe the flow velocity of the branch artery. Key words: Aortic aneurysms; Computational fluid dynamics; Streamliner multilayer flow modulator; Novel endovascular stent
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