{"title":"有机锂试剂直接功能化白磷制备有机磷化合物","authors":"Jingyuan Hu , Wei Liu , Wen-Xiong Zhang","doi":"10.1080/10426507.2021.2008933","DOIUrl":null,"url":null,"abstract":"<div><p>The direct synthesis of organophosphorus compounds from white phosphorus (P<sub>4</sub>) has very important scientific significance and application value. The review focuses on the direct functionalization of white phosphorus by organolithium reagents to organophosphorus compounds, including three parts: (i) the development of P<sub>4</sub> functionalization by organo-<em>mono</em>-lithium reagents, and the recent breakthroughs for the synergistic activation strategy of Lewis acid and organo-<em>mono</em>-lithium reagents; (ii) the new discovery of organo-<em>di</em>-lithium reagents mediated P<sub>4</sub> activation, including the aggregation states of products, reaction mechanism and derivatization reactions; and (iii) modes of organolithium reagents mediated P<sub>4</sub> activation. This timely review will accelerate the development of P<sub>4</sub> functionalization for the construction of organophosphorus compounds.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Direct functionalization of white phosphorus by organolithium reagents to organophosphorus compounds\",\"authors\":\"Jingyuan Hu , Wei Liu , Wen-Xiong Zhang\",\"doi\":\"10.1080/10426507.2021.2008933\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The direct synthesis of organophosphorus compounds from white phosphorus (P<sub>4</sub>) has very important scientific significance and application value. The review focuses on the direct functionalization of white phosphorus by organolithium reagents to organophosphorus compounds, including three parts: (i) the development of P<sub>4</sub> functionalization by organo-<em>mono</em>-lithium reagents, and the recent breakthroughs for the synergistic activation strategy of Lewis acid and organo-<em>mono</em>-lithium reagents; (ii) the new discovery of organo-<em>di</em>-lithium reagents mediated P<sub>4</sub> activation, including the aggregation states of products, reaction mechanism and derivatization reactions; and (iii) modes of organolithium reagents mediated P<sub>4</sub> activation. This timely review will accelerate the development of P<sub>4</sub> functionalization for the construction of organophosphorus compounds.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1042650722011509\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1042650722011509","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Direct functionalization of white phosphorus by organolithium reagents to organophosphorus compounds
The direct synthesis of organophosphorus compounds from white phosphorus (P4) has very important scientific significance and application value. The review focuses on the direct functionalization of white phosphorus by organolithium reagents to organophosphorus compounds, including three parts: (i) the development of P4 functionalization by organo-mono-lithium reagents, and the recent breakthroughs for the synergistic activation strategy of Lewis acid and organo-mono-lithium reagents; (ii) the new discovery of organo-di-lithium reagents mediated P4 activation, including the aggregation states of products, reaction mechanism and derivatization reactions; and (iii) modes of organolithium reagents mediated P4 activation. This timely review will accelerate the development of P4 functionalization for the construction of organophosphorus compounds.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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