有和没有甲状腺疾病的受试者脑脊液中的甲状腺自身抗体:对桥本脑病的影响

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM Journal of Thyroid Research Pub Date : 2015-12-21 DOI:10.1155/2015/819072
I. Ilias, V. Karagiorga, G. Paraskevas, A. Bougea, Maria Bourbouli, A. Pappa, S. Nikopoulou, E. Kapaki
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引用次数: 5

摘要

介绍。血浆抗甲状腺过氧化物酶(anti-TPO)和抗甲状腺球蛋白抗体(anti-Tg)被广泛用于自身免疫性甲状腺炎的诊断。目前还没有研究将健康人血浆和脑脊液中的抗tpo和抗tg与-à-vis甲状腺疾病患者进行比较。方法。我们检测了9例甲状腺功能减退患者(平均年龄±SD: 73±6岁)和9例无甲状腺疾病患者(平均年龄±SD: 73±8岁)血浆和脑脊液中抗tpo和抗tg抗体。结果。与有甲状腺和无甲状腺疾病的受试者相比,脑脊液中抗tpo自身抗体的浓度都很低(P = 0.007)。甲状腺疾病患者脑脊液抗tg自身抗体滴度与血浆相比非常低(P = 0.004),而非甲状腺疾病患者脑脊液抗tg自身抗体滴度与血浆相比差异无统计学意义(P = 0.063)。结论。血浆和脑脊液中甲状腺自身抗体水平低;我们没有观察到甲状腺自身抗体从外周血到脑脊液的任何转移。因此,对于桥本脑病(血液中经常检测到抗甲状腺自身抗体升高),甲状腺炎和脑病更有可能是非特异性的,但不同的,侵袭性免疫系统的事件。
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Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto's Encephalopathy
Introduction. Plasma antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-Tg) are widely used in the diagnosis of autoimmune thyroiditis. No research has compared anti-TPO and anti-Tg both in plasma and cerebrospinal fluid (CSF) of healthy individuals vis-à-vis patients with thyroid disease. Methods. We measured anti-TPO and anti-Tg antibodies in plasma and CSF in nine subjects (mean age ± SD: 73 ± 6 years) with hypothyroidism and nine subjects (mean age ± SD: 73 ± 8 years) without thyroid disease. Results. The concentration of anti-TPO autoantibodies in CSF was very low compared to plasma in both subjects with thyroid and without thyroid disease (P = 0.007). CSF anti-Tg autoantibodies titers were very low compared to the plasma in subjects with thyroid disease (P = 0.004), whereas, in subjects without thyroid disease, this difference did not reach statistical significance (P = 0.063). Conclusions. Thyroid autoantibodies levels were low in plasma and CSF; we did not observe any transfer of thyroid autoantibodies from the peripheral blood to the CSF. Therefore, regarding Hashimoto's encephalopathy, where elevated antithyroid autoantibodies are often measured in blood, it is more likely that thyroiditis and encephalopathy represent nonspecific, but distinct, events of an aggressive immune system.
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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
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