细粒曲霉发育过程与细胞周期调控的相互作用

Peter M. Mirabito, Stephen A. Osmani
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引用次数: 15

摘要

细粒曲霉是一种多细胞真菌,用于研究发育调控和细胞周期调控。这两个过程背后的遗传和分子机制已经被描述。两种类型的观察表明,细胞周期和发育调节机制之间存在显著的相互作用。首先,泡桐的发育涉及特化细胞类型的形成,这些细胞类型包含不同但特定的细胞核数量,这些细胞核在细胞周期进程中受到不同的调节。其次,直接影响核分裂的突变可能对发育过程中的细胞分化产生重大影响。在本文中,我们描述了这些相互作用,并指出了形态发生和细胞周期之间的串扰的潜在机制,这些机制可用于未来的实验研究。
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Interactions between the developmental program and cell cycle regulation of Aspergillus nidulans

Aspergillus nidulans is a multicellular fungus being used to study developmental regulation and cell cycle regulation. Genetic and molecular mechanisms underlying both processes have been characterized. Two types of observations suggest that there is significant interaction between cell cycle and developmental regulatory mechanisms. First, A. nidulans development involves the formation of specialized cell types that contain different, but specific, numbers of nuclei that are differentially regulated for cell cycle progression. Second, mutations directly affecting nuclear division can have major affects on cell differentiation during development. In this essay we describe these interactions and point out potential mechanisms for the cross talk between morphogenesis and the cell cycle that are tractable for future experimental investigation.

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