成人HIV血清阳性病例中CD4+ t淋巴细胞和肝酶的变化模式

S. Usman, G. Agboola, N. O. Akintayo-Usman, I. Isola, Florence Chinwe Umeozulu, P. Osho, Mattew T. Oluwole
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引用次数: 1

摘要

目标:艾滋病毒/艾滋病是撒哈拉以南非洲迅速蔓延的流行病。HIV是一种逆转录病毒,主要感染人体免疫系统的组成部分,如CD4+ t细胞、巨噬细胞和树突状细胞。因此,本研究旨在评估接受高效抗逆转录病毒治疗(HAART)、尚未开始HAART治疗的成人HIV血清阳性受试者以及HIV血清阴性对照受试者的CD4+ t细胞计数和肝酶。方法:采用流式细胞术检测受试者血清CD4+计数水平,酶法分光光度法检测血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)和碱性磷酸酶(ALP)水平。结果:与其他两组相比,HAART组血清ALT明显升高。此外,与对照组相比,HAART组血清ALP显著升高,而HAART组血清AST高于HAART初治组。结论:HAART与肝毒性相关,因此,建议在开始抗逆转录病毒治疗前后和/或切换HAART治疗方案时定期测量肝酶,这将是疾病监测和/或进展的良好指标。
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Patterns of CD4+ T-lymphocytes and liver enzymes in adult HIV seropositive cases -
Objectives: HIV/AIDS is a rapidly growing epidemic in sub-Saharan Africa. HIV is a retrovirus that primarily infects components of the human immune system such as CD4+ T-cells, macrophages and dendritic cells. This study is therefore designed to evaluate the CD4+ T-cell count and liver enzymes of adult HIV seropositive subjects receiving Highly Active Antiretroviral Therapy (HAART) and those yet to be started on HAART as well as HIV seronegative control subjects. Methods: Serum levels of CD4+ counts of subjects were determined using flow cytometry while their serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were determined using enzymatic spectrophotometric method. Results: Serum ALT was found to be significantly increased in the HAART group as compared with those of the two other groups. In addition, serum ALP was significantly increased in the HAART group as compared with the control subjects, while serum AST was higher in the HAART group as compared with the HAART naive group. Conclusion: HAART is associated with hepatotoxicity, thus, it is recommended that liver enzymes should be measured before and periodically after antiretroviral therapy is initiated and/or when HAART regimen is switched, as this will serve a good index for disease monitoring and/or progression.
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