l -抗坏血酸-异麦芽石体系中一种分子共轭物的形成与结构研究

I. Cherepanov, Viktoria Tretyakova
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引用次数: 0

摘要

l -抗坏血酸分子复合物与各种生物活性物质的形成为生产一种有望用于制药、食品和化妆品工业的新型药物开辟了道路。本研究涉及在乙醇水溶液(40%)中获得l -抗坏血酸与异麦芽石结合物的可能性研究。分离目标产物的方法包括将含有等摩尔量(0.001 mmol)组分的溶液恒温(50℃,1小时),然后缓慢溶剂去除24小时(25℃)。作者通过连续采样,用分子光谱方法研究了地层过程动力学。电子光谱中350 Nm处的光密度值和红外-傅里叶溶液光谱中1,674和1,754 cm−1处的光密度值表明,在温度状态控制过程中,组分没有破坏。当用四氯化碳或乙醚处理时,溶剂去除后得到的糖浆团块含有大量溶剂,结晶成淡黄色粉末(0.32 g,冰点在146.6℃)。有人用红外傅立叶光谱法研究了它的结构。作者在透射模式下(在KBr片中)记录了光谱,并使用扩散反射法记录了分子络合物形成的吸收带特征位置的变化。高频区的透射光谱表明,1- o糖基化异麦芽石组分参与了与抗坏血酸的结合。分离产物的扩散反射光谱中的C=C、C−O和C−O−H键振荡带相对于它们在初始组分光谱中的低频区位置的移位表明烯二醇抗坏血酸片段与无环异麦石组分的次羟基相互作用。所研究的分子偶联物的结构类似物是很有前途的抗氧化制剂。这决定了其性质的进一步研究的相关性。
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Formation and Structure Research of a Molecular Conjugate in the L-Ascorbic Acid – Isomaltite System
The formation of L-ascorbic acid molecular complexes with various biologically active substances opens the way to the production of a new drug type promising for the pharmaceutical, food and cosmetic industries use. The research concerns the possibility study of obtaining a conjugate of L-ascorbic acid with isomaltite in an aqueous ethanol (40 %) medium. The method of the target product isolating involves thermostating a solution containing equimolar amounts (0.001 mmol) of components (50 °C, 1 hour), followed by slow solvent removal for 24 hours (25 °C). The authors examined formation processes dynamics by molecular spectroscopy methods through sequential sampling. The optical density values at 350 Nm in the electronic spectra and 1,674 and 1,754 cm−1 bands position in the IR-Fourier solution spectra indicate the components destruction absence during thermostate control. When treated with carbon tetrachloride or diethyl ether, the syrupy mass obtained after solvent removal containing significant solvent amounts crystallizes a yellowish powder (0.32 g, ice point at 146.6 °C). A man studied its structure by the IR-Fourier spectroscopy. The authors recorded the spectra in the transmission mode (in the KBr tablets) and using the diffusion reflection method enabling to record changes in the absorption bands characteristic positions of the molecular complex formation. The transmission spectra of the high-frequency area indicate the 1-O-glycosylated isomaltite component involvement in the conjugation with ascorbic acid. The shifts of the C=C, C−O and C−O−H bond oscillation bands in the diffusion reflection spectrum of the isolated product relative to their position in the initial component spectra in the low-frequency area indicate the endiol ascorbic acid fragment interaction with the secondary OH groups of the acyclic isomaltite component. Structural analogues of the studied molecular conjugate are promising antioxidant preparations. This determines the further study relevance of its properties.
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来源期刊
Agro Food Industry Hi-tech
Agro Food Industry Hi-tech 工程技术-生物工程与应用微生物
CiteScore
0.29
自引率
0.00%
发文量
0
审稿时长
6-12 weeks
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