结核病危险因素与结核病患者血清维生素d水平的关系

Fadlan Hafizh Harahap
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引用次数: 1

摘要

背景:结核病(TB)是由结核分枝杆菌引起的一种侵袭各器官的传染病。结核病的危险因素包括年龄、性别、营养状况、艾滋病毒感染、糖尿病史、皮质类固醇使用和原发性结核病史。长期结核病导致血清中维生素D水平下降。目的:探讨结核病患者血清维生素D水平与危险因素的关系。方法:采用横断面设计进行分析。该研究的样本是Haji Adam Malik综合医院、Teladan和Amplas初级卫生中心Medan的30名符合纳入和排除标准的结核病患者。结果:Pearson相关检验显示BMI与维生素D水平呈负相关(p = 0.007;r = -0.482),年龄与维生素D水平无显著关系。Fisher精确检验发现维生素D水平与皮质类固醇使用(p = 1000)、糖尿病史(p = 0.469)、HIV合并感染和原发性结核病(p = 1000)之间没有关联。结论:BMI值与维生素D水平呈负相关。没有发现维生素D水平与年龄、皮质类固醇使用和糖尿病史之间的联系。
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THE ASSOCIATION BETWEEN TUBERCULOSIS RISK FACTORS AND VITAMIN D SERUM LEVEL ON TUBERCULOSIS PATIENS
Background: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis which attacks various organs. Tuberculosis has risk factors for age, sex, nutritional status, HIV infection, history of diabetes, corticosteroid use, and history of primary TB. Prolonged tuberculosis causes a decrease in vitamin D levels in blood serum.Objective: This study aims to look at the association of risk factors to serum vitamin D levels in TB sufferersMethod: Research conducted is analytic with cross-sectional design. The sample of the study were 30 patients with TB in Haji Adam Malik General Hospital, Teladan and Amplas primary health center Medan who had met the inclusion and exclusion criteria. Results: Pearson correlation test showed there was an inverse correlation between BMI and vitamin D levels (p = 0.007; r = -0.482) and there was no significant relationship between age and vitamin D levels. Fisher exact test found no association between vitamin D levels on corticosteroid use (p = 1,000), history of diabetes (p = 0.469), HIV coinfection, and primary TB (p = 1,000). Conclusion: In conclusion, there is an inverse correlation between the BMI value and vitamin D levels. No association was found between vitamin D levels and age, corticosteroid use, and history of diabetes.  
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