NOVEL SYNTHESIS OF [1,2,4]-TRIAZOLO-QUINAZOLINONE AND PYRIMIDINE DERIVATIVES MEDIATED BY CERIC AMMONIUM NITRATE (CAN)

A highly efficient, clean and simple protocol has been established for the synthesis of [1,2,4]-triazolo-quinazolinone and [1,2,4]-triazolo-pyrimidine derivatives in the presence of CAN. This CAN was effective for the one-pot multicomponent reaction of aromatic aldehyde, dimedone or ethyl acetoacetate and 3-amino-1,2,4-triazole in acetonitrile under mild reaction conditions. The present work shows attractive features, such as the short reaction time, excellent yield, mild reaction condition, easily isolated the product and no need of chromatographic separation.