苯、甲苯、乙苯和二甲苯:目前生物监测的分析技术和方法

IF 3.6 3区 化学 Q2 CHEMISTRY, ANALYTICAL Reviews in Analytical Chemistry Pub Date : 2020-01-01 DOI:10.1515/revac-2020-0116
E. Soleimani
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引用次数: 9

摘要

苯、甲苯、乙苯和二甲苯(BTEX)是一组挥发性有机化合物,人体接触它们可能导致包括癌症在内的一些疾病的发展。生物监测在职业接触化学品工人的暴露评估中起着重要作用。已经提出了几种代谢物用于暴露于BTEX的个体的生物监测。用于测定呼出空气中未代谢BTEX及其尿液代谢产物的提取方法和分析技术多种多样。本文综述了BTEX的毒性动力学、样品制备和分析方法。探讨了BTEX的代谢物,为接触这些化学品的工人寻找可靠的生物监测代谢物。此外,综述了呼出空气中未代谢BTEX及其代谢物的分析方法,并在选择性、灵敏度、简易性、时间、环境友好性和成本等方面进行了比较。考虑到样品制备的最新趋势,包括小型化、自动化、高通量性能和与分析仪器的在线耦合,微萃取技术,特别是填充吸附剂微萃取技术似乎是测定BTEX代谢物的首选方法。
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Benzene, toluene, ethylbenzene, and xylene: Current analytical techniques and approaches for biological monitoring
Abstract Benzene, toluene, ethylbenzene, and xylene (BTEX) are a group of volatile organic compounds that human exposure to them may result in the development of some diseases, including cancer. Biological monitoring plays an important role in exposure assessment of workers occupationally exposed to chemicals. Several metabolites have been proposed for biological monitoring of individuals who are exposed to BTEX. There are a variety of extraction methods and analytical techniques for the determination of unmetabolized BTEX in exhaled air and their urinary metabolites. The present study aimed to summarize and review the toxicokinetics of BTEX and sample preparation and analytical methods for their measurement. Metabolites of BTEX are discussed to find out reliable ones for biological monitoring of workers exposed to these chemicals. In addition, analytical methods for unmetabolized BTEX in exhaled air and their metabolites were reviewed in order to obtain a comparison between them in term of selectivity, sensitivity, simplicity, time, environmental-friendly and cost. Given the recent trends in sample preparation, including miniaturization, automation, high-throughput performance, and on-line coupling with analytical instrument, it seems that microextraction techniques, especially microextraction by packed sorbents are the methods of choice for the determination of the BTEX metabolites.
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来源期刊
Reviews in Analytical Chemistry
Reviews in Analytical Chemistry 化学-分析化学
CiteScore
7.50
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.
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