三种不同人群中ABC药物转运基因13个成员的单核苷酸多态性特征

Zihua Wang, S. Chong, Caroline G. L. Lee
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引用次数: 1

摘要

为了评估两个公共数据库(HapMap和Perlegen)在促进这些基因多态性与药物反应相关研究方面的有用性,我们检测了新加坡华人、欧洲美国人和非洲裔美国人的13个ABC转运基因的111个单核苷酸多态性。我们发现,来自HapMap/Perlegen数据库的基因型数据通常可转移到同一种群的不同样本和居住在其他地方的相似种群。然而,并不是所有的abc转运体家族基因都适合snp标记,因为低ld基因的标记效率低,节省的成本微不足道。因此,可能必须探索低ld ABC基因的替代方法。
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Characterization of Single Nucleotide Polymorphisms in 13 Members of the ABC Drug Transporter Genes in Three Different Populations
To evaluate the usefulness of the two public databases, HapMap and Perlegen, in facilitating studies associating polymorphisms in these genes with drug response, we examined 111 single-nucleotide-polymorphisms from 13 ABC- transporter genes in Singaporean-Chinese, European-Americans and African-Americans. We found that genotype data from the HapMap/Perlegen databases are generally transferable to different sampling of the same population and to simi- lar populations residing elsewhere. However, not all ABC-transporter family genes are amenable to SNP-tagging due to the low tagging-efficiency of low-LD genes resulting in negligible cost-savings. Hence, alternative approaches may have to be explored for low-LD ABC genes.
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