恶性肿瘤中BLACAT1的功能及机制

Q4 Medicine 中国医师杂志 Pub Date : 2020-03-20 DOI:10.3760/CMA.J.CN431274-20190401-00375

Shuwa Xu, Hao-Ming Xia, Zewei Gao, R. Huang, Enyu Tang, Xing-ming Jiang

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引用次数: 0

摘要

长链非编码rna (Long non-coding rna, lncRNAs)是一类长度超过200nt，由于缺乏开放阅读框而不具备蛋白质编码能力的转录本。然而，lncrna可以在转录和转录后水平以各种方式参与肿瘤的发生和进展。膀胱癌相关转录本1 (BLACAT1)是位于人染色体1q32.1上的lncRNA，在多种肿瘤(膀胱癌、胃癌、肺癌等)中异位表达，通过不同机制调控肿瘤细胞增殖、抗凋亡、侵袭转移，导致肿瘤的发生发展。本文就BLACAT1在恶性肿瘤中的作用及机制的研究进展进行综述。关键词:RNA，长链非编码;膀胱癌相关转录本1;肿瘤;治疗目标;审查

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The functions and mechanisms of BLACAT1 in malignant tumors

Long non-coding RNAs (lncRNAs) are a kind of transcripts which are longer than 200nt and have not protein-coding ability due to the lack of an open reading frame. However, lncRNAs can be involved in tumorigenesis and progression in various ways at the transcriptional and post-transcriptional levels. Bladder cancer associated transcript 1 (BLACAT1) as a lncRNA located on human chromosome 1q32.1, is ectopic expression in various tumors (bladder cancer, gastric malignant tumor, lung carcinoma, et al) and can regulate tumor cell proliferation, anti-apoptosis, invasion and metastasis by different mechanisms leading to occurrence and development of tumors. In this review, we summarized current studies of the functions and mechanisms of BLACAT1 in malignant tumors. Key words: RNA, long noncoding; Bladder cancer associated transcript 1; Neoplasms; Therapeutic target; Review

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