通过气相色谱-质谱分析芦荟的植物化学特征,并在NCBI上进行化合物活性验证,用于植物的工业增值

Pankaj Kushwaha, Mansi Shrivastava, Diksha Pandey, Kalpana Verma, L. Dwivedi
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摘要

芦荟通常被称为Gwarpatha或Ghrit Kumari,被认为是万能的万灵药。它是健康、美容、医药和护肤行业的一种天赋植物。但是,考虑到它在其他部门也有多种用途,除了已知的工业和医疗价值之外,还需要进一步探索它的其他用途。本研究强调了该植物的其他工业和药用特性。包括初步植物化学物质筛选、MEAV叶片甲醇提取物的GC-MS分析以及在PubChem、Drug Bank等NCBI国际化合物数据库中查找化合物活性。在通过GC-MS检测到的200个化合物中,有46个化合物落在主要峰区,在化合物数据库中进行了进一步的探索。因此,α-D葡萄糖、乳糖、麦芽糖、丁酸香茅酯、叶绿醇、肉豆蔻酸、癸酸、十六烷酸等关键植物化合物在食品甜味调节剂、乳制品、酒精、软饮料、保健、美容、糖果和制药等行业具有重要的工业活性;面霜、洗发水、肥皂、香水产品中的保湿和芳香剂;乳化剂、质地增强剂;润滑油、油脂、染料、塑料、洗涤剂、生物柴油等的助剂。此外,还发现了几种具有抗癌、抗炎、抗氧化、降压、抗真菌、抗菌、增强免疫力、类风湿关节炎、急性呼吸窘迫综合征、哮喘、心血管疾病、癌症、骨质疏松、失眠等药用特性的植物化合物。因此,芦荟具有巨大的工业价值,可以成为食品、饮料、化妆品、洗涤剂、肥皂、生物柴油、制药等其他几个行业的良好原料来源,并且可能被认为是可持续种植芦荟的替代经济作物,如本德尔坎德地区等干旱易发地区。
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The phytochemical profiling of Aloe vera through GC-MS and compounds activity validation at NCBI for industrial value addition of the plant
The Aloe vera commonly known as Gwarpatha or Ghrit Kumari is considered as a universal panacea. It is a gifted plant for the health, beauty, medicinal and skincare industry. However, considering the multiple uses of it in other sectors also, it needed to be explored further for other than known industrial and medicinal values. The present study highlights the additional industrial and medicinal properties of the plant. It includes preliminary phytochemicals screening, GC-MS analysis of a Methanolic Extract of Aloe vera (MEAV) leaves and finding out the compounds activities at the international compounds databases of NCBI like PubChem, Drug Bank etc. Out of 200 compounds detected through GC-MS, mainly 46 compounds falling in major peak areas were further explored at the compounds databases. Accordingly, some key phytocompounds such as α-D Glucose, Lactose, Maltotriose, Citronellyl Butyrate, Phytol, Myristic Acid, Capric Acid, Heptadecanoic Acid etc. depicted the important industrial activities like sweet modulator of food stuff, diluents/sweetener for dairy, alcohol, soft drinks, health, beauty, confectionary and pharmaceutical industry; moisturizing and fragrance agent in cream, shampoo, soap, perfumed products; emulsifier, texture enhancer; agent for the lubricants, greases, dyes, plastics, detergent and biodiesel etc. Other than them, several phytocompounds showing medicinal properties like anti-cancer, anti-inflammatory, antioxidant, anti-hypertensive, anti-fungal, anti-bacterial, immunity booster, therapeutic agents for Rheumatoid Arthritis, acute respiratory distress syndrome, Asthma, Cardiovascular Disease, Cancer, Osteoporosis, Insomnia, etc. were also identified in the plant. Consequently, Aloe vera with its great industrial values can be a good source of raw material for several other industries like food, beverage, cosmetic, detergent, soaps, biodiesel pharmaceutical and may be considered for the sustainable aloe-cultivation as alternative cash crop in drought prone area like Bundelkhand region.
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