Synthesis and Characterization of Thiadiazole Pyrazolene Anthranilic Acid Derivatives as Potent Anti-inflammatory Agents

Several new substituted thiadiazole pyrazolene anthranilic acid derivatives were synthesized. These compounds also evaluated for their anti-inflammatory and analgesic activities. Compound 2-((5-(3- (2,6-dichloro)acrylamido)-1,3,4-thiadiazol-2-yl)methyl amino)-benzoic acid (5b) and 2-((5-(1-acetyl- 5-(2,6-dichloro)-4,5-dihydro-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)methyl amino)benzoic acid (6b) were found to be most active compounds of this series, which exhibits 38.10 & 48.50% anti-inflammatory activity while, 36.24 & 40.10 % analgesic activity, respectively. The structures of all the compounds were characterized by analytical data, IR, 1H NMR and mass spectrometry.