COVID-19大流行对肾素-血管紧张素系统的新挑战

S. Yanev, T. Stoyanova
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摘要

在抗击新型冠状病毒(SARS-CoV-2)全球流行的斗争中,对主要病毒攻击部位的认识,即所谓的“入口”,可以提供一种潜在的有效预防/治疗方法。攻击的目标是肾素-血管紧张素系统(RAS)的重要平衡单元,血管紧张素转换酶2 (ACE2),它调节血管紧张素II (Ang II)的水平,而Ang II具有血管收缩和炎症功能。在具有病理性心血管症状和血压升高的患者中,通过抑制ACE1合成酶或阻断血管紧张素受体反应(ATR)来维持最佳的Ang II。本文试图解决以下问题:在RAS功能失衡(表现为SARS-CoV-2流行的结果)中,ACE1抑制剂的治疗效果会发生变化吗?方向是什么?
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New challenges to renin-angiotensin-system in COVID-19 pandemic
In the fight against the global epidemic from the new corona virus (SARS-CoV-2), awareness on the site of the primary viral attack, the so-called „entry port“ enables an implies efficient prophylactic/therapeutic approach The attack is aimed at the important balancing unit of the renin-angiotensin system (RAS), angiotensin-converting enzyme 2 (ACE2), which regulates the level of angiotensin II (Ang II) While Ang II has vasoconstrictor and inflammatory functions, the ACE2 converted product of Ang-(1-7) possesses vasodilating and anti-inflammatory functions In patients with pathological cardiovascular symptoms and increased blood pressure, maintenance of optimal Ang II is achieved by inhibiting the synthesizing enzyme ACE1 or blocking the angiotensin receptor response (ATR) In this Dance Round, an attempt is made to address the question: In the unbalanced functions of RAS (manifesting as an outcome of SARS-CoV-2 epidemic), will the therapeutic effect of ACE1 inhibitors change and in what direction?
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