下颌骨切除及重建对下颌骨生长影响的实验研究。2. 下颌骨缺损的修复效果[j]。下颌骨缺损的修复效果

Koichi Yamamoto
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引用次数: 0

摘要

生长时期的骨缺损会造成下颌生长障碍。骨切除后,通过骨移植或陶瓷种植重建下颌骨缺损,维持下颌骨形态和功能,但对下颌骨生长的影响尚未有详细的研究。因此,笔者对羟基磷灰石(HA)和磷酸三钙(TCP)两种陶瓷在手术所致下颌骨缺损生长中的作用进行了实验研究。本研究选用96只4周龄WKA大鼠。取36只大鼠进行组织学研究,60只平均分为以下6组:第一组;骨移植于下颌骨体下缘缺损处。组2。将骨移植到下颌支中心的缺损处。组3。将纤维蛋白粘连系统(Tisseel®kit)填充到与1组相同的骨缺损中。组4。采用纤维蛋白黏附系统将骨移植到与1组相同的骨缺损处。5组。将透明质酸与纤维蛋白黏附系统植入与1组相同的骨缺损。6组。与1组相同,将纤维蛋白黏附系统植入TCP。15周龄处死60只大鼠,取其头颅,用测量法、接触显微放射照相法和放射线照相法对所得标本进行评价。下颌骨下缘切除后,将切除的骨本身再植于切除部位,可明显改善下颌骨生长抑制,但在下颌分支中心缺损处填充骨对下颌骨生长无明显影响。下颌骨下缘缺损的陶瓷植入效果与骨再植相似,但效果不显著。
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Experimental studies of the influence of mandible resection and effects of its reconstruction on the growth of the mandible. 2. Effects of reconstruction of mandibular bone defects.:2. Effects of reconstruction of mandibular bone defects
Bone defects in the growing period give rise to mandibular growth obstruction. After the bone is resected, the defect in the mandible is reconstructed by means of bone graft or ceramic implantation to maintain mandible form and function, but the effect on mandibular growth has not been studied in detail. So the author has studied experimentally the effects of bone graft and the implantation of 2 types of ceramics, hydroxylapatite (HA) and tricarcium phosphate (TCP), in surgically caused mandible defects growth.Ninety-six 4-week-old WKA rats were used in this study. Of these 36 rats were used for histological study and 60 were divided equally into the 6 following groups: Group 1. Bone was grafted into the defect at the mandibular body inferior border. Group 2. Bone was grafted into the defect at the mandibular ramus center. Group 3. Fibrin adhesion system (Tisseel ® kit) was filled into the bone defect created the same as in group 1. Group 4. Bone was grafted with fibrin adhesion system into the bone defect created the same as in group 1. Group 5. HA was implanted with fibrin adhesion system into the bone defect created the same as in group 1. Group 6. TCP was implanted with fibrin adhesion system into the defect created the same as in group 1. Sixty of the rats were sacrified at 15 weeks of age, decapitated, and the obtained specimens were evaluated by measurement, contact microradiography and radiography.Growth inhibition of the mandible after resection of the mandible inferior border was significantly improved by replantation of the removed bone itself to the resected site, but there was no significant effect on mandible growth when the defect at the mandibular ramus center was filled with bone. Ceramics implantation into the defect of the mandible inferior border showed a similar but not significant effect to that seen in the case of bone replantation.
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