熵与生理学的结合:我们应该将衰老解读为紊乱吗?

IF 4 2区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY STEM CELLS Pub Date : 2024-02-08 DOI:10.1093/stmcls/sxad084
Marco Tatullo
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引用次数: 0

摘要

衰老的特点是一些生理过程和生物途径的改变,导致对与年龄有关的疾病和死亡的易感性增加。通常情况下,多潜能干细胞/祖细胞可能有助于组织稳态,并尽量减少年龄相关的DNA损伤。科学研究表明,衰老诱导了一些复杂的变化,甚至影响了间充质基质/干细胞(MSCs)自我更新、分化和免疫调节人体组织的能力,也导致了局部微环境的进一步改变。因此,细胞衰老可以被认为是对几种损害的总体反应。因此,衰老似乎创造了适当的条件来降低组织的代谢性能和细胞间的交流,导致组织的渐进破坏;另一方面,间充质干细胞的功能似乎严重降低。这篇简明的综述总结了在衰老过程中影响间充质干细胞的主要改变,并解释了炎症在年龄相关综合征中的关键作用。该假说提出了热力学概念“熵”和生物老化之间的平行关系,推测两者都可以在不可逆系统中增加,并且都导致不可逆的混乱;所以,问题是:我们应该把衰老翻译成疾病吗?
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Entropy Meets Physiology: Should We Translate Aging as Disorder?

Aging is characterized by an alteration of several physiological processes and biological pathways that leads to an increased susceptibility to age-related diseases and death. Normally, multipotential stem/progenitor cells may contribute to tissue homeostasis, and to minimize the age-depending DNA damage. Scientific research has demonstrated that aging induces several complex changes affecting even the mesenchymal stromal/stem cells (MSCs) ability to self-renew, differentiate, and immunomodulate the human tissues, causing further alterations in the local microenvironment. Cellular senescence can thus be considered as an overall response to several damages. Accordingly, aging seems to create the proper conditions to decrease the tissue's metabolic performance, and the cell-to-cell communication, resulting in a progressive tissue destruction; on the other hand, the MSCs functions appear to be severely reduced. This concise review summarizes the main alterations affecting the MSCs during aging, and it also explains the role of inflammation as a key player in age-related syndromes. The hypothesis is to suggest a parallelism between the thermodynamic concept of "entropy" and biological aging, speculating that both can increase within irreversible systems and both lead toward an irreversible disorder; so, the question is: should we translate aging as disorder?

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来源期刊
STEM CELLS
STEM CELLS 医学-生物工程与应用微生物
CiteScore
10.30
自引率
1.90%
发文量
104
审稿时长
3 months
期刊介绍: STEM CELLS, a peer reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. STEM CELLS is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. STEM CELLS covers: Cancer Stem Cells, Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells, Regenerative Medicine, Stem Cell Technology: Epigenetics, Genomics, Proteomics, and Metabonomics, Tissue-Specific Stem Cells, Translational and Clinical Research.
期刊最新文献
A de novo Missense Mutation in PPP2R5D Alters Dopamine Pathways and Morphology of iPSC-derived Midbrain Neurons. High-throughput solutions in tumor organoids: From culture to drug screening. USP13 Overexpression in BMSCs Enhances Anti-Apoptotic Ability and Guards Against Methylprednisolone-Induced Osteonecrosis in Rats. Advantages of Cell Proliferation and Immune Regulation in CD146+NESTIN+ HUMSCs: Insights from Single-Cell RNA Sequencing. RSPO/LGR signaling regulates proliferation of adult hippocampal neural stem cells.
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