短期和长期给予HAART治疗对HIV患者线粒体和氧化的影响。

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics Current clinical pharmacology Pub Date : 2020-01-01 DOI:10.2174/1574884714666190905162237
Joy E Ikekpeazu, Oliver C Orji, Ikenna K Uchendu, Lawrence U S Ezeanyika
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引用次数: 11

摘要

背景:在HIV患者中使用HAART与氧化应激相关的线粒体功能障碍之间可能存在联系。我们评估了短期和长期给药HAART对在尼日利亚埃努古埃努古州立大学教学(ESUT)医院接受短期和长期治疗的HIV患者线粒体和氧化的影响。方法:96例患者被分为4组,每组24人。第1组由年龄匹配、明显健康、血清阴性的个体组成(无艾滋病毒组);第2组由没有开始任何形式治疗的HIV血清阳性个体组成(治疗naïve组)。第3组为已知接受HAART治疗不足一年的HIV患者(短期治疗组),第4组为接受HAART治疗超过一年的HIV患者(长期治疗组)。所有患者年龄在18到60岁之间,在研究期间都在HIV诊所就诊。测定总抗氧化状态(TAS,单位为nmol/l)、丙二醛(MDA,单位为mmol/l)、CD4+细胞计数/μl和基因组研究均采用标准操作程序。结果:我们发现,与短期治疗组和无HIV组相比,长期治疗组MDA水平显著升高,TAS显著降低(p结论:长期使用HAART治疗会增加HIV患者的氧化应激并导致线粒体改变。
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Mitochondrial and Oxidative Impacts of Short and Long-term Administration of HAART on HIV Patients.

Background: There may be a possible link between the use of HAART and oxidative stress-related mitochondrial dysfunction in HIV patients. We evaluated the mitochondrial and oxidative impacts of short and long-term administration of HAART on HIV patients attending the Enugu State University Teaching (ESUT) Hospital, Enugu, Nigeria following short and long-term therapy.

Methods: 96 patients categorized into four groups of 24 individuals were recruited for the study. Group 1 comprised of age-matched, apparently healthy, sero-negative individuals (the No HIV group); group 2 consisted of HIV sero-positive individuals who had not started any form of treatment (the Treatment naïve group). Individuals in group 3 were known HIV patients on HAART for less than one year (Short-term treatment group), while group 4 comprised of HIV patients on HAART for more than one year (Long-term treatment group). All patients were aged between 18 to 60 years and attended the HIV clinic at the time of the study. Determination of total antioxidant status (TAS in nmol/l), malondialdehyde (MDA in mmol/l), CD4+ count in cells/μl, and genomic studies were all done using standard operative procedures.

Results: We found that the long-term treatment group had significantly raised the levels of MDA, as well as significantly diminished TAS compared to the Short-term treatment and No HIV groups (P<0.05). In addition, there was significantly elevated variation in the copy number of mitochondrial genes (mtDNA: D-loop, ATPase 8, TRNALEU uur) in the long-term treatment group.

Conclusion: Long-term treatment with HAART increases oxidative stress and causes mitochondrial alterations in HIV patients.

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Current clinical pharmacology
Current clinical pharmacology PHARMACOLOGY & PHARMACY-
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期刊介绍: Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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