HIV-1与SARS-CoV-2交叉对中枢神经系统影响的研究进展

IF 3.7 2区 医学 Q2 INFECTIOUS DISEASES Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-11-11 DOI:10.1007/s11904-023-00676-8
Ferron F Ocampo, Pathariya Promsena, Phillip Chan
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引用次数: 0

摘要

综述目的:研究表明,在艾滋病毒感染者(PWH)的COVID-19急性和后续阶段,有无数的神经和心理健康表现。本文综述了PWH患者感染SARS-CoV-2后中枢神经系统(CNS)预后的最新进展,并强调了这一领域的现有知识空白。利用电子记录系统的研究强调,与未感染艾滋病毒(PWoH)的人相比,PWH患者发生COVID-19急性和持续性神经系统并发症的风险过高。然而,神经影像学以及血液和脑脊液(CSF)标志物研究明显缺乏,这些研究可以证实这两种感染之间的潜在协同作用,特别是在接受抑制性抗逆转录病毒治疗的PWH中。考虑到SARS-CoV-2与HIV之间潜在的相互作用尚不清楚,临床医生应对COVID-19后PWH中新发或恶化的神经症状保持警惕,因为它们可能与任何一种感染有关。
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Update on Central Nervous System Effects of the Intersection of HIV-1 and SARS-CoV-2.

Purpose of review: Research has shown myriad neurologic and mental health manifestations during the acute and subsequent stages of COVID-19 in people with HIV (PWH). This review summarizes the updates on central nervous system (CNS) outcomes following SARS-CoV-2 infection in PWH and highlight the existing knowledge gaps in this area.

Recent findings: Studies leveraging electronic record systems have highlighted the excess risk of developing acute and lingering neurological complications of COVID-19 in PWH compared to people without HIV (PWoH). However, there is a notable scarcity of neuroimaging as well as blood and cerebrospinal fluid (CSF) marker studies that can confirm the potential synergy between these two infections, particularly in PWH receiving suppressive antiretroviral therapy. Considering the unclear potential interaction between SARS-CoV-2 and HIV, clinicians should remain vigilant regarding new-onset or worsening neurological symptoms in PWH following COVID-19, as they could be linked to either infection.

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来源期刊
Current HIV/AIDS Reports
Current HIV/AIDS Reports INFECTIOUS DISEASES-
CiteScore
8.10
自引率
2.20%
发文量
45
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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